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Autologous stem cell transplantation in first-line treatment of high-risk aggressive non-Hodgkin’s lymphoma

In: NEOPLASMA, vol. 55, no. 2
A.vranovsky - M. Ladicka - J. Lakota
Detaily:
Rok, strany: 2008, 107 - 112
O článku:
A single center, retrospective analysis evaluating the outcome of patients with poor-risk aggressive non-Hodgkin’s lymphoma (NHL) treated with high-dose chemotherapy and autologous stem cell transplantation (ASCT) as a part of firstline therapy. Forty-seven patients younger than 65 years with diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), peripheral T-cell lymphoma (PTCL) or alk-negative anaplastic large cell lymphoma (ALCL) underwent ASCT between July 1997 and November 2005. Patients with DLBCL and alk-negative ALCL had 2 or 3 age-adjusted International Prognostic Index risk factors. All patients were transplanted after MACOP-B induction therapy followed by 2 courses of DHAP and myeloablative chemotherapy BEM or CBV. The complete response rate to the high-dose therapy was 79% with an estimated 5-year progression-free survival of 66%. At a median follow-up of 35 months (range, 16 to 112 months) the estimated overall survival at five years was 59%. There were 4 treatment-related deaths. Twenty-nine of 47 patients remain in complete remission. Our results confirm the efficacy of high-dose therapy with ASCT during first-line treatment of patients with poor-prognosis aggressive lymphoma, with substantial number of patients cured by using this treatment approach. Key words: high-dose chemotherapy; autologous transplantation, aggressive non-Hodgkin’s lymphoma
Ako citovať:
ISO 690:
, A., Ladicka, M., Lakota, J. 2008. Autologous stem cell transplantation in first-line treatment of high-risk aggressive non-Hodgkin’s lymphoma. In NEOPLASMA, vol. 55, no.2, pp. 107-112. 0028-2685.

APA:
, A., Ladicka, M., Lakota, J. (2008). Autologous stem cell transplantation in first-line treatment of high-risk aggressive non-Hodgkin’s lymphoma. NEOPLASMA, 55(2), 107-112. 0028-2685.