In: NEOPLASMA, vol. 55, no. 2
D. Feltl - J. Marková - H. Mocikova - K. Dedeckova - T. Kozak
Detaily:
Rok, strany: 2008, 96 - 100
O článku:
The purpose of the study is to determine incidence and prognostic impact of osseous Hodgkin lymphoma (HL). Between
1997 and 2004, 198 patients with HL were treated at our institution. Advanced stages and nodular sclerosis histology
prevailed. All patients were treated according to protocols of the German Hodgkin Study Group (GHSG). After minimum
follow-up of 24 months, we retrospectively analyzed the incidence of osseous HL, treatment response and parameters of
survival. We recorded 14 cases of osseous HL (7 %), always with concurrent nodal disease. Axial skeleton was most
frequently involved. Eleven patients (78,5 %) achieved complete remission and three (21,5 %) progressed primarily. The
patients with osseous HL had significantly lower 2-year freedom from treatment failure than the patients without bone
involvement (71,4 and 92,7 %, respectively, p=0,004), with no significant difference in 2-year overall survival (85,7 and
95 %, respectively, p=0,14). On multivariate analysis, advanced stage was the only independent adverse prognostic factor. In conclusion, bone involvement is a relatively common finding in HL and is not an independent adverse prognostic factor.
Key words: Hodgkin lymphoma – bone involvement – prognostic factors
Ako citovať:
ISO 690:
Feltl, D., Marková, J., Mocikova, H., Dedeckova, K., Kozak, T. 2008. Prognostic impact of bone involvement in Hodgkin lymphoma. In NEOPLASMA, vol. 55, no.2, pp. 96-100. 0028-2685.
APA:
Feltl, D., Marková, J., Mocikova, H., Dedeckova, K., Kozak, T. (2008). Prognostic impact of bone involvement in Hodgkin lymphoma. NEOPLASMA, 55(2), 96-100. 0028-2685.