In: NEOPLASMA, vol. 54, no. 5
K. Piekutowski - R. Makarewicz - B. Zachara
Detaily:
Rok, strany: 2007, 374 - 378
O článku:
and in antioxidative defense of the organism. There is a correlation between the concentration of selenium, activity of
glutathione peroxidases (GSH-Px), and other parameters of antioxidative defense in blood components. The above mentioned
factors were suggested to play an important role in etiopathogenesis of neoplastic diseases. Therefore, the aim of our present
study was to compare the selenium status and GSH-Px activity in the plasma of 22 healthy women, 50 individuals suffering
from cancer of uterine cervix, uterine corpus or ovary, and 49 women diagnosed with benign neoplasia of the uterine corpus
or ovary. In addition, the selenium concentration was measured in postoperative cancer tissues, benign tumors, and
histopatologically healthy surgical margins of the aforementioned patients.
An average selenium concentration and GSH-Px activity in blood plasma of cancer patients and benign neoplasia patients
was significantly lower than in the plasma of healthy women. It suggests that lower overall selenium status and lower
selenium-dependent antioxidative capacity of the organism might partly contribute to development of neoplastic diseases of
reproductive system.
Postoperative tissues of patients revealed significantly higher selenium concentrations in cancer tissues of uterine cervix
and corpus, and benign tumors of uterine corpus, as compared to corresponding healthy tissue margins. Higher accumulation
of selenium in these neoplastic tissues might reflect a compensatory up-regulation of antioxidant defense systems in tumors
that often undergo a persistent oxidative stress.
Key words: selenium, glutathione peroxidase, reactive oxygen species, carcinogenesis, cancer of reproductive system
Ako citovať:
ISO 690:
Piekutowski, K., Makarewicz, R., Zachara, B. 2007. The antioxidative role of selenium in pathogenesis of cancer of the female
reproductive system. In NEOPLASMA, vol. 54, no.5, pp. 374-378. 0028-2685.
APA:
Piekutowski, K., Makarewicz, R., Zachara, B. (2007). The antioxidative role of selenium in pathogenesis of cancer of the female
reproductive system. NEOPLASMA, 54(5), 374-378. 0028-2685.