In: NEOPLASMA, vol. 54, no. 5
J. Prausova - T. Eckschlager - M.mrhalova - A. Slobodnik - K. Kubáčková - S. Vinakurau - R. Kodet
Detaily:
Rok, strany: 2007, 407 - 412
O článku:
Selection of breast carcinoma therapy is based on standard prognostic markers, such as tumor size, infiltration of
regional lymph nodes, tumor grade, and expression of hormonal receptors. Insufficient treatment results stimulate a search
for new markers which may lead to a more precise characterization of these tumors and to a more effective treatment. In
our study we determined essential clinical and histopathological characteristics of non-metastasizing breast cancer -
primary tumor size, involvement of the regional lymph nodes, expression of hormonal receptors and a status of ERBB-2
protein (HER-2), DNA ploidy, and their possible inter-correlation. In this study 77 patients were analyzed. The mean age
was 59.3 years. Tumor stage T1 was found in 53%, T2 in 39%, T3 in 5% of patients. 57% of patients did not show any
metastases in the axillary lymph nodes. A higher tumor grade 3 was seen mainly in larger tumors, in 62% of T2 and 66%
of T3 tumors; 77% of carcinomas expressed hormonal receptors. HER-2 expression was shown in 21 T1 tumors, 13 T2
tumors, and 1 T3 tumor. 47 tumors were diploid. 13 T1 tumors, 14 T2 tumors, and 2 T3 tumors were aneuploid. Any
significant correlation among staging T, N and ERBB-2 expression, hormonal receptors expression, tumor grade and
DNA ploidy was found
Key words: Breast Cancer, Hormonal receptor, ERB-2 expression, Ploidity
Ako citovať:
ISO 690:
Prausova, J., Eckschlager, T., , M., Slobodnik, A., Kubáčková, K., Vinakurau, S., Kodet, R. 2007. Clinical, Pathological and Molecular Characteristics of Newly
Diagnosed Breast Cancers. In NEOPLASMA, vol. 54, no.5, pp. 407-412. 0028-2685.
APA:
Prausova, J., Eckschlager, T., , M., Slobodnik, A., Kubáčková, K., Vinakurau, S., Kodet, R. (2007). Clinical, Pathological and Molecular Characteristics of Newly
Diagnosed Breast Cancers. NEOPLASMA, 54(5), 407-412. 0028-2685.