In: NEOPLASMA, vol. 54, no. 5
I. Kocáková - M. Svoboda - K. Kubosova - V. Chrenko - E. Roubalova - E. Krejci - R. Sefr - P. Slampa - T. Frgala - J. Žaloudík
Detaily:
Rok, strany: 2007, 447 - 453
O článku:
synthase (TS), thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) mRNAs in rectal carcinoma.
55 patients with locally advanced rectal carcinoma (cT3-4, N0, M0 or cT2-4,N+, M0) were treated with capecitabine 825
mg/m2 twice a day and pelvic radiotherapy 1,8 Gy daily up to cumulative dose of 45 Gy, boosting up to 50,4 Gy. Patients
underwent surgery 6th week after the completion of chemoradiotherapy. Biopsies of rectal carcinoma were taken before
starting therapy and 14 days after its cesation. Biopsies were examined for TS, DPD and TP mRNA levels. CEA in serum
was examined to monitor relapses.
Both TP and TS mRNA increase two weeks after starting therapy (p<0,001). TP mRNA median levels were elevated 2,3x
after starting therapy. Moreover responders exhibit 1,5x higher induction than non-responders both before and after starting
therapy, but difference is significant before therapy only (p=0,017). Non-responders have most frequent TS induction. Complete
remission was observed in 17% and substantial responses with microscopic residuum only in additional 19% of cases were
achieved. The pathologic downstaging rate was 76%.
Our data show that TS and TP mRNA are induced by preoperative chemoradiotherapy in both responders and
nonresponders. TP induction is in accordance with the expected role of TP in the activation of capecitabine and the known
promoting role of TP in tissue fibrosis frequently associated with tumor regression
Key words: Thymidine Phosphorylase Induction, Thymidylate Synthase, Preoperative Chemoradiotherapy, Capecitabine,
Rectal Cancer
Ako citovať:
ISO 690:
Kocáková, I., Svoboda, M., Kubosova, K., Chrenko, V., Roubalova, E., Krejci, E., Sefr, R., Slampa, P., Frgala, T., Žaloudík, J. 2007. Preoperative Radiotherapy and Concomitant Capecitabine Treatment
Induce Thymidylate Synthase and Thymidine Phosphorylase mRNAs
in Rectal Carcinoma. In NEOPLASMA, vol. 54, no.5, pp. 447-453. 0028-2685.
APA:
Kocáková, I., Svoboda, M., Kubosova, K., Chrenko, V., Roubalova, E., Krejci, E., Sefr, R., Slampa, P., Frgala, T., Žaloudík, J. (2007). Preoperative Radiotherapy and Concomitant Capecitabine Treatment
Induce Thymidylate Synthase and Thymidine Phosphorylase mRNAs
in Rectal Carcinoma. NEOPLASMA, 54(5), 447-453. 0028-2685.