In: NEOPLASMA, vol. 54, no. 4
J. Hochmann
Detaily:
Rok, strany: 2007, 290 - 296
O článku:
The ratio of cytosol concentrations of estrogen receptors to progesterone receptors (ER/PR) can help at the diagnosis of
the excessive production of estrogens or (on the contrary) of the lowered function of ER or of the too small expression of the
PR gene. We divided the statistical set into the groups with the approximately same concentrations of PR for stronger
judgement of this ratio because PR is nearly not changing due to the age (in contrast to the age unstable ER). We used this
stratification into the PR-limited groups at the radio-receptor analysis of 147 patients.
1) The ER/PR quotient was higher in the older patients but predominantly it was approximately 10-times lower in case of
the high PR than in case of the low PR. This is why the more than 10-fould error can arise at uncorrected judgement whether
ER of some patient is inadequately high or low in the comparison with her PR. It implies that e.g. in case of any one patient
it is possible to infer the excessive production of ER from the comparison of her ER/PR – best only in the range of her PRlimited
group (and in the addition – taking account of the age). It can be important for therapy and prognosis.
2) The interpersonal differences of ER and ER/PR were approximately 10-times smaller in PR-limited groups than in the
whole statistical set. This is why e.g. the correlation coefficients of the age increase of ER and ER/PR in the PR-limited
groups were more favourable than in the whole non-stratified statistical set.
In case if PR decreases in the higher age in case of some authors, it is necessary to create the PR-limited groups by
another manner. For instance, 20 % of the tumors with the highest PR from each age group will be in the same PR-limited
group (despite the fact that they differ in PR). The impact of the age will be then more marked in case of ER/PR than in case
of ER only because the numerator elevates and denominator decreases. The impact of the ovarian cycle might be detected
more sensitively on the same principle.
It is possible to analyse by this manner the possibility to transform the receptor results to the average age or to the optimal
phase of the ovulation cycle to prevent e.g. the false negativity of ER. The principles of this mathematical approach might be
exploited even for a judgement of the prognosis and therapy on the basis of the mutual ratio of different isotypes of receptors
for one hormone only (ERα / ERβ or PRA / PRB). It concerns not only the breast cancers but also the cancers of the uterus.
Key words: Breast cancer, estrogen receptors, progesterone receptors, ratio ER to PR, isotypes (ERα / ERβ or PRA /
PRB), estrogens, age, ovarian cycle, hormonal therapy.
Ako citovať:
ISO 690:
Hochmann, J. 2007. Ratio of concentrations of estrogen receptors to progesterone receptors
(ER/PR) in the cytosol of breast cancers (stratification by forming
of groups differing in PR). In NEOPLASMA, vol. 54, no.4, pp. 290-296. 0028-2685.
APA:
Hochmann, J. (2007). Ratio of concentrations of estrogen receptors to progesterone receptors
(ER/PR) in the cytosol of breast cancers (stratification by forming
of groups differing in PR). NEOPLASMA, 54(4), 290-296. 0028-2685.