In: NEOPLASMA, vol. 54, no. 4
S. Zang - Ch. Ji - Xun Qu - X. Dong - D. Ma - J. Ye - R. Ma - J. Dai - D. Guo
Detaily:
Rok, strany: 2007, 304 - 310
O článku:
Breast cancer is one of the leading causes of cancer death in women. The Notch family of proteins plays crucial roles in
determining cell fates such as proliferation, differentiation and apoptosis. A role for Notch signaling in human breast cancer
has been suggested by the development of adenocarcinomas in the murine mammary gland. However, it is not clear currently
whether Notch signaling is frequently expressed and activated in breast cancers. Here we show that Notch signaling is
overexpressed and highly activated in breast cancers. More significantly, the attenuation of Notch signaling by γ-secretase
inhibitor can inhibit the proliferation of breast cancer cells by both causing cell cycle arrest and apoptosis. Thus, targeting
Notch signaling may be of therapeutic value in breast cancers.
Key words: Human breast cancer; Notch; γ-secretase inhibitor; Cell cycle; Apoptosis
Ako citovať:
ISO 690:
Zang, S., Ji, C., Qu, X., Dong, X., Ma, D., Ye, J., Ma, R., Dai, J., Guo, D. 2007. A study on notch signaling in human breast cancer. In NEOPLASMA, vol. 54, no.4, pp. 304-310. 0028-2685.
APA:
Zang, S., Ji, C., Qu, X., Dong, X., Ma, D., Ye, J., Ma, R., Dai, J., Guo, D. (2007). A study on notch signaling in human breast cancer. NEOPLASMA, 54(4), 304-310. 0028-2685.