Effect of an induced mild form of hyperhomocysteinemia on the function and ß-amyloid peptide accumulation in the rat heart: Is there some heart-brain axis?: Homocysteine in heart-brain axis

Strany: 19 - 27

Jazyk: eng

OBJECTIVES: Modifying risk factors remains a primary strategy for preventing cardio- and cerebrovascular disease (CVD), and although treatment options for modifiable factors have expanded, effective management in practice remains challenging. Studies link Alzheimer's disease (AD) with CVD manifested by hypertension and intra‐ and extra- cranial atherosclerosis and arteriosclerosis. Elevated plasma homocysteine (Hcy) level is recognized as a CVD risk factor, with even mild elevations linked to endothelial dysfunc- tion. However, the exact role of Hcy in CVD is still uncertain. Moreover, AD-mediated degeneration of the brain's neuro-signalling pathways, together with a potential peripheral amyloid accumulation, may have detrimental effects on other organs, including the heart. MATERIAL & METHODS: In this study, Wistar rats received daily subcutaneous Hcy injec- tions (1.2 μmol/g/day) for three weeks. After the treatment, the animals were sacrificed, and their hearts were perfused on a Langendorff system with Krebs – Henseleit solution. The hearts were fixed in formalin and prepared for histological and immunohistochemical analyses. RESULTS: The hHcy group showed increased perfusion pressure, reduced left ventricular end-diastolic pressure (LVDP), and lower heart contraction and relaxation indexes (+LV dP/dt and –LV dP/dt). Structural changes in the Hcy-treated group included increased cell volume, cardiomyocyte disintegration, and elevated programmed cell death occurrence. Immunohistochemical results revealed β-amyloid peptide deposits in Hcy-treated animals. CONCLUSION: These findings indicate that hHcy affects heart microcirculation and cardio- myocytes, leading to changes in heart structure and function. These changes could be linked to the progression of the brain's neuro-signaling pathways dysregulation and likely future neurodegeneration

ISO 690:

Kovalska, M., Hnilicová, P., Leskova Majdova, K., Tatarkova, Z., Lehotský, J., Kalenska, D. 2025. Effect of an induced mild form of hyperhomocysteinemia on the function and ß-amyloid peptide accumulation in the rat heart: Is there some heart-brain axis?: Homocysteine in heart-brain axis. In Activitas Nervosa Superior Rediviva, vol. 67, no.1, pp. 19-27. 1337-933X. DOI: https://doi.org/10.31577/ansr.2025.67.1.3

APA:

Kovalska, M., Hnilicová, P., Leskova Majdova, K., Tatarkova, Z., Lehotský, J., Kalenska, D. (2025). Effect of an induced mild form of hyperhomocysteinemia on the function and ß-amyloid peptide accumulation in the rat heart: Is there some heart-brain axis?: Homocysteine in heart-brain axis. Activitas Nervosa Superior Rediviva, 67(1), 19-27. 1337-933X. DOI: https://doi.org/10.31577/ansr.2025.67.1.3

Vydavateľ: Centrum Experimentálnej medicíny SAV, v. v. i.