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The effects of ethanol and aqueous extracts of Moringa oleifera leaves on learning, spatial memory and anxiety in male mice

In: Activitas Nervosa Superior Rediviva, vol. 66 , no. 3-4 (EN)
Nematollah Pahlavan Jahaghi - Mandana Gholami - Amir Modarresi Chahardehi
Detaily:
Rok, strany: 2024, 125 - 134
Jazyk: eng
Kľúčové slová:
Moringa oleifera; learning; memory; anxiety; Barnes Maze; Elevated Plus Maze
URL originálneho zdroja: www.rediviva.sav.sk
Typ článku: Oriiginal article
Typ dokumentu: journal article
O článku:
OBJECTIVE: Moringa oleifera leaves are widely used in the treatment of a variety of disorders such as cognitive deficits. Several studies show that M. oleifera 's leaves, roots, and seeds all contain high levels of micronutrients, which enhance brain function. The objective of this study is to investigate and compare the effects of ethanolic and aqueous extracts of M. oleifera leaves on spatial memory and anxiety-like behavior at various doses. METHOD: Thirty male mice were randomly divided into five groups (n = 6) and administrated those extracts via intraperitoneal injection for 30 consecutive days. Behavioral assays were performed using the Barnes maze and elevated plus maze tests. RESULTS: No significant change was observed in the final body weight. Both aqueous and ethanol extracts lead to improved learning and memory by reducing errors. However ethanol extract at 200 mg/kg had a greater effect on improving learning and memory, and did not enhance anxiety compared to the other doses. CONCLUSION: Ethanol extract of M. oleifera leaves in high dose has a more positive cognitive effect rather than aqueous extract of M. oleifera leaves.
Ako citovať:
ISO 690:
Jahaghi, N. P., Gholami, M., Modarresi Chahardehi, A. 2024. The effects of ethanol and aqueous extracts of Moringa oleifera leaves on learning, spatial memory and anxiety in male mice. In Activitas Nervosa Superior Rediviva, vol. 66 , no.3-4 (EN), pp. 125-134. 1337-933X. DOI: https://doi.org/10.31577/ansr.2024.66.3.4

APA:
Jahaghi, N. P., Gholami, M., Modarresi Chahardehi, A. (2024). The effects of ethanol and aqueous extracts of Moringa oleifera leaves on learning, spatial memory and anxiety in male mice. Activitas Nervosa Superior Rediviva, 66 (3-4 (EN)), 125-134. 1337-933X. DOI: https://doi.org/10.31577/ansr.2024.66.3.4
O vydaní:
Vydavateľ: Centre of Experimental Medicine SAS, v. v. i.
Publikované: 19. 12. 2024
Verejná licencia:

This work is licensed under CC BY-NC-ND 4.0