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New [1,2,4]triazolo[4,3-c]quinazoline enhances cisplatin- and temozolomide-induced growth inhibition and apoptosis in HL-60 cells

In: NEOPLASMA, vol. 54, no. 1
L. Cipak - S. Letasiova - A. Repicky - S. Jantova
Detaily:
Rok, strany: 2007, 16 - 20
O článku:
The purpose of this study was to investigate the therapeutic potential of a newly synthesized [1,2,4]triazolo[4,3- c]quinazoline (NTCHMTQ) alone and in combination with two anticancer drugs (cisplatin and temozolomide) against HL- 60 leukemia cell line. The IC50 value of NTCHMTQ toward HL-60 cells was 19.7 μM. No apoptosis and cell cycle changes were observed in cells treated with 5 μM NTCHMTQ alone. Combination of non-toxic concentrations of NTCHMTQ (1 – 5 μM) with cisplatin or temozolomide sensitized HL-60 cells to these two drugs and significantly enhanced their efficacies, that is illustrated by combination indexes, sub-G0 cell fraction, apoptotic DNA fragmentation and caspase-3 activity. The results suggest that combined therapy of non-toxic concentrations of NTCHMTQ with chemotherapeutics may provide synergistic regimen for treatment of leukemia. However, further in vitro and in vivo experimental drug-cell and drug-drug studies are warranted. Key words: chemotherapy, modulator, quinazoline, apoptosis, cisplatin, temozolomide
Ako citovať:
ISO 690:
Cipak, L., Letasiova, S., Repicky, A., Jantova, S. 2007. New [1,2,4]triazolo[4,3-c]quinazoline enhances cisplatin- and temozolomide-induced growth inhibition and apoptosis in HL-60 cells. In NEOPLASMA, vol. 54, no.1, pp. 16-20. 0028-2685.

APA:
Cipak, L., Letasiova, S., Repicky, A., Jantova, S. (2007). New [1,2,4]triazolo[4,3-c]quinazoline enhances cisplatin- and temozolomide-induced growth inhibition and apoptosis in HL-60 cells. NEOPLASMA, 54(1), 16-20. 0028-2685.