In: NEOPLASMA, vol. 53, no. 6
K. Figova - J. Hrabeta - T. Eckschlager
Detaily:
Rok, strany: 2006, 457 - 462
O článku:
Oncolytic viruses infect, replicate in, and eventually lyse tumor cells but spare normal ones. In addition to direct lysis,
a result of viral replicative cycle, viruses also mediate tumor cell destruction by inducing nonspecific and specific antitumor
immunity. Some viruses express proteins that are cytotoxic to tumor cells. Viruses recognized as oncolytic agents can therefore
be divided into three categories: 1/ naturally occurring viruses (e.g. Newcastle disease virus, vesicular stomatitis virus,
autonomous parvoviruses, some measles virus strains, reovirus) that selectively replicate in tumor cells, in some instances
owing to their relative resistance to interferon action; 2/ virus mutants in which some genes essential for replication in normal
cells but evitable in cancer cells have been deleted (e.g.adenovirus ONYX 015 that replicates only in cells with defected
p53 or herpes virus G207 which exacts the presence of ribonucleotide reductase); 3/ virus mutants modified by the introduction
of tissue-specific transcriptional elements that drive viral genes (e.g.adenovirus CV706 that has PSA restricted expression
of E1A and E1B and adenovirus adMycTK that binds selectively on myc protein).
Reovirus is prevalent in the human population but not associated with any known human disease. Studies have shown that
reovirus multiplicate preferentially in tumor cells with activated gene of ras family or ras-signaling pathway while sparing
normal cells. Activated ras or its pathway could be found in as many as 60-80% of human malignancies. In our studies we
used cell lines that demonstrably express activated ras. We showed the cytopathic effect of reovirus (serotype 3 strain
Dearing) on medulloblastoma cell lines and compared it with its acting on normal human fibroblasts. Oncolytics Biotech
Inc. is currently guiding three Phase I or Phase I/II Reolysin studies, and has completed two clinical studies and concluded
enrolment in a third one.
Ako citovať:
ISO 690:
Figova, K., Hrabeta, J., Eckschlager, T. 2006. Reovirus - possible therapy of cancer. In NEOPLASMA, vol. 53, no.6, pp. 457-462. 0028-2685.
APA:
Figova, K., Hrabeta, J., Eckschlager, T. (2006). Reovirus - possible therapy of cancer. NEOPLASMA, 53(6), 457-462. 0028-2685.