In: NEOPLASMA, vol. 53, no. 5
M. Lazarová - J. Lábaj - G. Kogan - D. Slameňová
Detaily:
Rok, strany: 2006, 434 - 439
O článku:
The connection between dietary intake of carboxymethyl chitin-glucan (CM-CG, approximately 200 mg/kg body
weight, during 21 days) and the response of freshly isolated rat
cells to genotoxic treatment with a combination of
photosensitizer Methylene Blue and visible light (MB+VL) was
evaluated in presented study. Blood lymphocytes, testicular
cells, and hepatocytes were isolated from rats fed by a standard
or CM-CG enriched diet and in ex vivo conditions challenged
with oxidative agent. Induced DNA damage was assessed using a
modified comet assay.
When added to the diet, CM-CG itself did not induce any negative
effect on the health condition of animals or on level of
DNA breaks in rat cells. Moreover, the cells isolated from CM-CG
fed animals were more resistant to oxidative stress induced
by visible light-excited Methylene Blue.
In conclusion, we have demonstrated that carboxymethyl chitin-glucan represents a natural fungal polysaccharide that is
able to exert antimutagenic properties upon application in diet.
Ako citovať:
ISO 690:
Lazarová, M., Lábaj, J., Kogan, G., Slameňová, D. 2006. Carboxymethyl chitin-glucan enriched diet exhibits protective
effects against oxidative DNA damage induced in freshly isolated
rat cells. In NEOPLASMA, vol. 53, no.5, pp. 434-439. 0028-2685.
APA:
Lazarová, M., Lábaj, J., Kogan, G., Slameňová, D. (2006). Carboxymethyl chitin-glucan enriched diet exhibits protective
effects against oxidative DNA damage induced in freshly isolated
rat cells. NEOPLASMA, 53(5), 434-439. 0028-2685.