In: NEOPLASMA, vol. 53, no. 3
T. Wróbel - M. Poreba - G. Mazur - R. Poreba - A. Pyszel - B. Beck - A. Steinmetz-Beck - R. Andrzejak - K. Kuliczkowski
Detaily:
Rok, strany: 2006, 253 - 258
O článku:
High serum VEGF and bFGF levels are independent prognostic factors
of poor prognosis in NHL patients. There is growing
evidence that both angiogenesis and haemostatic aberrancies are
integral parts of the pathobiology of cancer growth and
dissemination. The purpose of the study was: (a) to analyze
relations of VEGF and bFGF serum levels, fibrinogen and
D-dimer plasma levels with lymphoma Ann Arbor Staging System
(AASS) and International Prognostic Index (IPI) and, (b)
to evaluate correlations between serum levels of angiogenic
cytokines and plasma levels of coagulation-fibrinolysis factors
in 52 previously untreated NHL patients included to the study.
The control group consisted of 23 healthy volunteers. Serum VEGF,
bFGF and plasma D-dimer levels were measured by
enzyme-linked immunosorbent assay (ELISA). Plasma levels of
fibrinogen were determined on Behring Coagulation System
(BCS) equipment.
In lymphoma group serum VEGF and bFGF leves were significantly
higher than in the control. Differences in concentrations
of VEGF, bFGF between II, III and IV stage of disease acc. AASS
were not statistically significant. Plasma levels of
fibrinogen and D-dimer were elevated in lymphoma patients when
compared with the control. Fibrinogen plasma levels
were similar in all stages. The D-dimer level was significantly
higher in patients with IV stage in comparison to stage II and
III. Statistically significant differences of VEGF and bFGF serum
levels were observed only between intermediate/high and
high risk groups acc. IPI. Fibrinogen plasma levels were
significantly higher in high risk group than in low risk group.
D-dimer plasma levels were significantly higher in high risk group
than in low risk group and low/intermediate group. We
observed positive correlation between serum level of VEGF and
plasma level of fibrinogen, and between serum level of
bFGF and plasma level of fibrinogen. There was also negative
correlation between serum level of VEGF and plasma level of
D-dimer, and between serum level of bFGF and plasma level of D-
dimer.
Our study indicates that D-dimer level, but not VEGF, bFGF and
fibrinogen correlates with AASS and IPI in NHL patients.
Significant correlations between levels of VEGF/bFGF and
fibrinogen/D-dimer suggest specific interactions between
angiogenic and coagulation-fibrinolysis system.
Ako citovať:
ISO 690:
Wróbel, T., Poreba, M., Mazur, G., Poreba, R., Pyszel, A., Beck, B., Steinmetz-Beck, A., Andrzejak, R., Kuliczkowski, K. 2006. Angiogenic and coagulation-fibrinolysis factors in non Hodgkin's lymphoma. In NEOPLASMA, vol. 53, no.3, pp. 253-258. 0028-2685.
APA:
Wróbel, T., Poreba, M., Mazur, G., Poreba, R., Pyszel, A., Beck, B., Steinmetz-Beck, A., Andrzejak, R., Kuliczkowski, K. (2006). Angiogenic and coagulation-fibrinolysis factors in non Hodgkin's lymphoma. NEOPLASMA, 53(3), 253-258. 0028-2685.