In: NEOPLASMA, vol. 53, no. 3
J. Prados - C. Melguizo - J.e. Fernández - E. Carrillo - J.a. Marchal - H. Boulaiz - A. Martínez - F. Rodriguez-Serrano - A. Aránega
Detaily:
Rok, strany: 2006, 226 - 231
O článku:
Effectiveness of conventional cytotoxic treatment of
rhabdomyosarcoma (RMS) may be limited by the development of
multidrug resistance (MDR) mediated by mdr1 gene. This gene codes
for P-glycoprotein (P-gp) which has been related to a
immunoregulatory function. Modulation of HLA expression by P-gp
has been described in different types of tumor cells including
RMS. However, very little is known about biological implications
of the P-gp expression in RMS patients treated
with conventional chemotherapy. In order to study the problem, we
used embryonal RMS tissue samples from treated patients.
Our results indicated that positive RMS samples to mdr1 show
higher HLA class I expression than those which were
negative to mdr1 PCR, what indicates a significant correlation
between the expression of both molecules. In addition, we developed
two resistant RMS cell lines (A-204-1 and 2) using similar
concentrations of actinomycin D as are plasma levels in
clinical situation. Both resistant cell lines showed mdr1
expression and an increase of HLA class I expression which was
dose-dependent. These results demonstrated that conventional
chemotherapy of embryonal RMS is able to induce resistance
which can modulate HLA class I expression and suggest that
immunological studies of these tumors may be necessary to the
design new specific therapeutic strategies.
Ako citovať:
ISO 690:
Prados, J., Melguizo, C., Fernández, J., Carrillo, E., Marchal, J., Boulaiz, H., Martínez, A., Rodriguez-Serrano, F., Aránega, A. 2006. Induction of drug resistance in embryonal rhabdomyosarcoma treated with conventional chemotherapy is associated with HLA class I increase. In NEOPLASMA, vol. 53, no.3, pp. 226-231. 0028-2685.
APA:
Prados, J., Melguizo, C., Fernández, J., Carrillo, E., Marchal, J., Boulaiz, H., Martínez, A., Rodriguez-Serrano, F., Aránega, A. (2006). Induction of drug resistance in embryonal rhabdomyosarcoma treated with conventional chemotherapy is associated with HLA class I increase. NEOPLASMA, 53(3), 226-231. 0028-2685.