In: NEOPLASMA, vol. 53, no. 3
D. Urbanová - L. Urban - A. Carter - D. Maasova - B. Mladosievičová
Detaily:
Rok, strany: 2006, 183 - 190
O článku:
Cardiotoxicity is a serious adverse effect of chemotherapy that
encompasses a spectrum of disorders, ranging from relatively
benign arrhythmias to potentially lethal conditions such as
myocardial ischemia/infarction and cardiomyopathy. The
toxicity of chemotherapeutic drugs can cause loss of myocytes' sarcolemmal integrity, release of bioactive markers into the
extracellular environment (tissue and circulation) and ultimately
leading to the necrosis of myocytes. The extent and severity
of the necrosis can be monitored by the levels of bioactive
markers.
Therefore current research is aimed at finding biochemical markers
with absolute cardiac specificity, high sensitivity and
predictive value that can be used in early detection of patients
with treatment-induced myocardial damage. Routinely used
biomarkers like CK, CK-MB, and myoglobin do not meet the stated
criteria. Their role in early diagnosis of chemotherapy-
induced myocardial toxicity is controversial and limited.
However, cardiac troponins, new nonconventional markers, have
shown promising results in assessment and monitoring
of both, early and late, clinical and subclinical damage to
myocardium after chemotherapy.
The article reviews clinical studies evaluating the role of
cardiac troponins in the diagnosis of cardiotoxicity and their use
in the management of cancer survivors.
Ako citovať:
ISO 690:
Urbanová, D., Urban, L., Carter, A., Maasova, D., Mladosievičová, B. 2006. Cardiac troponins — biochemical markers of cardiac toxicity after cytostatic therapy
Minireview. In NEOPLASMA, vol. 53, no.3, pp. 183-190. 0028-2685.
APA:
Urbanová, D., Urban, L., Carter, A., Maasova, D., Mladosievičová, B. (2006). Cardiac troponins — biochemical markers of cardiac toxicity after cytostatic therapy
Minireview. NEOPLASMA, 53(3), 183-190. 0028-2685.