In: NEOPLASMA, vol. 53, no. 2
G. Kirschnerová - A. Tóthová - O. Babušíková
Detaily:
Rok, strany: 2006, 150 - 154
O článku:
The AML1 gene, located in the chromosomal band 21q22, belongs to
the runt domain family of genes and encodes the
subunit of the core-binding factor (CBF). AML1 is normally
expressed in all hematopoietic lineages and is essential for the
transcriptional regulation of a number of hematopoietic specific
genes. In acute leukemia three types of abnormality of
AML1 have been observed — chromosomal translocations, point
mutation and duplication or amplification of the
unrearranged gene. The most common origin of extra copies of the
AML1 gene is polysomy of chromosome 21 or a partial
duplication of the long arm of chromosome 21, less frequently
ring, isochromosome or the tandem repetition of chromosome
21.
In the study 13 children and 5 adults with ALL and AML or MDS,
respectively, have been included. Using standard
G-banding and dual color FISH analyses, gain of AML1 originated in
polysomy of chromosome 21 in each group of patients
was proved. True high-level amplification was not observed but
some uncommon changes in noteworthy association with
other chromosome aberrations, age or diagnoses were presented.
Ako citovať:
ISO 690:
Kirschnerová, G., Tóthová, A., Babušíková, O. 2006. Amplification of AML1 gene in association with karyotype, age and
diagnosis in acute leukemia patients. In NEOPLASMA, vol. 53, no.2, pp. 150-154. 0028-2685.
APA:
Kirschnerová, G., Tóthová, A., Babušíková, O. (2006). Amplification of AML1 gene in association with karyotype, age and
diagnosis in acute leukemia patients. NEOPLASMA, 53(2), 150-154. 0028-2685.