In: NEOPLASMA, vol. 53, no. 1
P. Pouckova - J. Skvor - G. Gotte - F. Vottariello - J.t. Slavik - J. Matousek - D.v. Laurents - M. Libonati - J. Soucek
Detaily:
Rok, strany: 2006, 79 - 85
O článku:
Previously we have shown that monomeric RNase A has no significant
biological activity, whereas its oligomers (dimer
to tetramer) prepared by lyophilizing from 50% acetic acid
solutions, show remarkable aspermatogenic and antitumor activities.
Furthermore, conjugates prepared by chemical binding of native
RNase A to polyethylene glycol (PEG) have shown a
significant aspermatogenic and antitumor activities. In this work
we show that the chemical conjugation of PEG to the
RNase A C-dimer, and to the two RNase A trimers (NC-trimer and C-
trimer) decreases the aspermatogenic activity of the
oligomers while increasing their inhibitory activity on the growth
of the human UB900518 amelanotic melanoma transplanted
in athymic nude mice. Moreover, the PEG-conjugated RNaseA oligomers
are devoid, like the free oligomers, of any
embryotoxic activity.
Ako citovať:
ISO 690:
Pouckova, P., Skvor, J., Gotte, G., Vottariello, F., Slavik, J., Matousek, J., Laurents, D., Libonati, M., Soucek, J. 2006. Some biological actions of PEG-conjugated RNase A oligomers. In NEOPLASMA, vol. 53, no.1, pp. 79-85. 0028-2685.
APA:
Pouckova, P., Skvor, J., Gotte, G., Vottariello, F., Slavik, J., Matousek, J., Laurents, D., Libonati, M., Soucek, J. (2006). Some biological actions of PEG-conjugated RNase A oligomers. NEOPLASMA, 53(1), 79-85. 0028-2685.