In: NEOPLASMA, vol. 53, no. 1
L. Elbl - I. Vasova - Z. Kral - M. Navratil - L. Smardova - J. Vorlicek
Detaily:
Rok, strany: 2006, 62 - 66
O článku:
The prospective study was conducted to determine whether standard
regimen ABVD used in the treatment of Hodgkin's
disease is accompanied by the presence of early and chronic
myocardial impairment. The study comprised 52 patients (30
male and 22 female) aged 34+/-15 years (range 18—71; median 30) with
Hodgkin's disease and the control group with 40
healthy volunteers (21 male and 19 female) aged 40+/-8 years (range
20—70; median 38). The maximal administered cumulative
dose (CD) of doxorubicin was 297+/-50 mg/m2 (range 150—450; median
300). Radiotherapy of the mediastinum was delivered
to 27 (52%) patients with a mean dose 41+/-4 Gy (range 30—46; median
42). Echocardiography was performed at
baseline and before each course of chemotherapy. The control
examination was done at one month after the treatment and
after one year. The stress echocardiography was performed at one-year control. Significant change of ejection fraction (EF)
during the treatment was observed only in 10 (18%) patients (7
male/3 female) aged 29+/-13 years (range 18—56; median 22).
The mean toxic CD of doxorubicin was 170+/-33 mg/m2 (range 100—200;
median 175) and the mean time of the onset EF decline
was 13.3+/-3 weeks (range 8—16; median 14). These changes were
asymptomatic, and all patients completed the treatment
successfully. Four patients (8%) demonstrated significant
asymptomatic decline of EF after the chemotherapy. When
compared the value of EF after one-year examination, a stable
significant decline of EF in the sub-group with early toxicity
was found. Despite a difference in the rest EF, the exercise
increment of EF did not reveal any significant difference among
tested groups and the contractile reserve of the left ventricle in
patients was not impaired.
The present data shows that the treatment of Hodgkin's disease
with the standard ABVD regimen is accompanied with
mild early and chronic asymptomatic changes of the left
ventricular function. These changes were not reversible during
one-year follow-up.
Ako citovať:
ISO 690:
Elbl, L., Vasova, I., Kral, Z., Navratil, M., Smardova, L., Vorlicek, J. 2006. Echocardiographic evaluation of early and chronic cardiotoxicity in adult patients treated for Hodgkin's disease with ABVD regimen. In NEOPLASMA, vol. 53, no.1, pp. 62-66. 0028-2685.
APA:
Elbl, L., Vasova, I., Kral, Z., Navratil, M., Smardova, L., Vorlicek, J. (2006). Echocardiographic evaluation of early and chronic cardiotoxicity in adult patients treated for Hodgkin's disease with ABVD regimen. NEOPLASMA, 53(1), 62-66. 0028-2685.