In: NEOPLASMA, vol. 52, no. 6
R. Lohynska - A. Slavicek - A. Bahanan - P. Novakova
Detaily:
Rok, strany: 2005, 483 - 488
O článku:
The aim of the study was to assess the impact of factors that
could predict the probability of local failure in early laryngeal
squamous cell carcinoma treated with curative radiotherapy.
Sixty seven patients (12 women and 55 men) with laryngeal cancer
stage I (47 patients) and stage II (20 patients) were
treated from 1998 to 2003 with curative radiotherapy and
retrospectively evaluated.
Median follow-up was 36 months (3—80). Local relapse occured in 10
patients (15%), regional lymphnodes relapse affected
2 patients. The median time between start of radiotherapy to
recurrence was 13 months (3—48). Death due to cancer
occured in 4 patients (2 died from locoregional progression of the
recurrence and 2 from distant metastases), whereas 7 patients
died from non-cancer related causes. The 2-year overall survival
rate was 90% and 5-year OS was 79%. The 2-year local
control rate was 82% and 5-year local control was 79%. In the
univariate analysis there was a statistically significant decrease
in local control influenced by grading (p < 0.0001). High risk group
of relapse encompassed patients with at least two
negative factors: supraglottic tumor, women, radiotherapy
prolongation by 3 or more days and high grade tumor and has
3 times worse local control than low risk group (p=0.0125). The
highest risk of local reccurrence was in the first three years
after radiotherapy than later (p=0.0057). On multivariate analysis
unfavourable prognostic factors for local control were
gender (p=0.022), presence of 2 or more negative risk factors
(p=0.018) and lengths of follow up (p=0.005). Radiation dose,
stage, age, hemoglobin level and anterior commissure involvement
were not significant factors for local control. Overall
survival was affected both in the univariate and multivariate
analysis by presence of local relapse (p < 0.005) and follow up
duration (p < 0.02). Anemia had borderline significance for overall
survival in univariate analysis (p=0.064), but in the
multivariate analysis was significant unfavourable factor
(p=0.008). Other studied factors (radiation dose, anterior
commissure involvement and age) were not reaching level of
statistical significant value for overall survival.
Close follow up strategy is recommended for high risk group of
patients with two or more risk factors especially in the
first three years after radiation therapy.
Ako citovať:
ISO 690:
Lohynska, R., Slavicek, A., Bahanan, A., Novakova, P. 2005. Predictors of local failure in early laryngeal cancer. In NEOPLASMA, vol. 52, no.6, pp. 483-488. 0028-2685.
APA:
Lohynska, R., Slavicek, A., Bahanan, A., Novakova, P. (2005). Predictors of local failure in early laryngeal cancer. NEOPLASMA, 52(6), 483-488. 0028-2685.