In: NEOPLASMA, vol. 52, no. 6
Z. Ovesná - K. Horváthová-Kozics
Detaily:
Rok, strany: 2005, 450 - 455
O článku:
Cancer is one of the main causes of death in both men and women,
claiming over 6 million people each year worldwide.
Chemoprevention in combination with anti-cancer treatment is
therefore important to reduce morbidity and mortality.
Stilbene-based compounds have over the years attracted attention
of many researchers due to their wide ranging biological
activities. One of the most relevant and extensively studied
stilbenes is trans-resveratrol, a phytoalexin present in grapes and
other foods. One of the most striking biological activities of
trans-resveratrol soundly investigated during recent years has
been its cancer-chemopreventive potential. It has been found that
the biological activity of trans-resveratrol and its analogues
depends significantly on the structural determinants, which are
(i) number and position of hydroxyl groups, (ii)
intramolecular hydrogen bonding, (iii) stereoisomery and (iv)
double bond. The observation that trans-stilbene compounds
having 4´-hydroxy group, double bond and bearing ortho-diphenoxyl
or para-diphenoxyl functionalities possess remarkably
higher chemopreventive activity than trans-resveratrol gives us
useful information for further chemopreventive drug
design.
Ako citovať:
ISO 690:
Ovesná, Z., Horváthová-Kozics, K. 2005. Structure-activity relationship of trans-resveratrol and its analogues. In NEOPLASMA, vol. 52, no.6, pp. 450-455. 0028-2685.
APA:
Ovesná, Z., Horváthová-Kozics, K. (2005). Structure-activity relationship of trans-resveratrol and its analogues. NEOPLASMA, 52(6), 450-455. 0028-2685.