MiR-1203 is involved in hepatocellular carcinoma metastases and indicates a poor prognosis

Rok, strany: 2020, 267 - 276

Non-coding RNAs, especially miRNAs, have been shown to be important regulators in multiple human diseases, including malignant tumors, congenital disease, and autoimmune disease. In this study, we screened the metastasis-associated miRNAs in hepatocellular carcinoma (HCC). Based on the miRNA microarray screening, miR-1203 was confirmed to be the most significant miRNA and was also highly associated with HCC metastases. Bioinformatics prediction indicated direct binding of miR-1203 in SOCS3, which was also confirmed by a dual luciferase reporter assay, resulting in suppression of SOCS3. Increased miR-1203 also promoted invasion of HCC cells through suppressing SOCS3, while no effect on cell proliferation or apoptosis was detected. Circulating expression of miR-1203 and SOCS3 might serve as a predictor of metastases and poor prognosis in HCC patients. In conclusion, miR-1203 might promote HCC metastasis by decreasing SOCS3. MiR-1203 predicts a poor outcome in HCC patients and thus might serve as a potential therapeutic target for the prevention of HCC.

ISO 690:

Shi, J., Li, X., Hu, Y., Zhang, F., Lv, X., Zhang, X., Chen, Q., Hu, S. 2020. MiR-1203 is involved in hepatocellular carcinoma metastases and indicates a poor prognosis. In NEOPLASMA, vol. 67, no.2, pp. 267-276. 0028-2685. DOI: https://doi.org/10.4149/neo_2019_190414N328

APA:

Shi, J., Li, X., Hu, Y., Zhang, F., Lv, X., Zhang, X., Chen, Q., Hu, S. (2020). MiR-1203 is involved in hepatocellular carcinoma metastases and indicates a poor prognosis. NEOPLASMA, 67(2), 267-276. 0028-2685. DOI: https://doi.org/10.4149/neo_2019_190414N328

Vydavateľ: AEPress, Ltd.