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Expression of the Insulin Receptor Substrate 1 in primary tumors and lymph node metastases in breast cancer: correlations with Bcl-xL and Bax proteins

In: NEOPLASMA, vol. 52, no. 5
M. Koda - M. Sulkowska - L. Kanczuga-Koda - J. Golaszewska - W. Kisielewski - M. Baltaziak - A. Wincewicz - S. Sulkowski
Detaily:
Rok, strany: 2005, 361 - 363
O článku:
In our previous investigation Insulin Receptor Substrate 1 (IRS-1) correlated with proliferation marker Ki-67 in human breast cancer. The aim of the present study was to assess relationships between IRS-1 expression and antiapoptotic Bcl-xL as well as proapoptotic Bax proteins, assessed by immunohistochemistry, in primary tumors and lymph node metastases of breast cancer. IRS-1 is positively associated with both Bcl-xL and Bax in primary and metastatic tumors. Thus, our results could suggest that IRS-1 might affect turnover of cancer cells and breast cancer progression through activation of mitogenesis and participation in the regulation of the balance between anti- and proapoptotic pathways.
Ako citovať:
ISO 690:
Koda, M., Sulkowska, M., Kanczuga-Koda, L., Golaszewska, J., Kisielewski, W., Baltaziak, M., Wincewicz, A., Sulkowski, S. 2005. Expression of the Insulin Receptor Substrate 1 in primary tumors and lymph node metastases in breast cancer: correlations with Bcl-xL and Bax proteins. In NEOPLASMA, vol. 52, no.5, pp. 361-363. 0028-2685.

APA:
Koda, M., Sulkowska, M., Kanczuga-Koda, L., Golaszewska, J., Kisielewski, W., Baltaziak, M., Wincewicz, A., Sulkowski, S. (2005). Expression of the Insulin Receptor Substrate 1 in primary tumors and lymph node metastases in breast cancer: correlations with Bcl-xL and Bax proteins. NEOPLASMA, 52(5), 361-363. 0028-2685.