A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth

Rok, strany: 2019, 954 - 962

Non-small cell lung cancer (NSCLC) is the most prevalent subtype of lung cancer histologically, and an increasing number of evidences have shown during the past years that long non-coding RNAs (lncRNAs) are involved in tumorigenesis. Here we found a long non-coding RNA, GATA2-AS1, repressing NSCLC cells proliferation via regulating GATA2. GATA2-AS1 gene is located at antisense strand of GATA2 on chromosome while GATA2-AS1 RNA interacts with GATA1 protein at promoter region of GATA2 and then inhibits its transcription. Moreover, GATA2-AS1 is transcriptionally repressed by MYC in NSCLC cells. To conclude, our study discovered the role of lncRNA GATA2-AS1 in human non-small cell lung cancer growth thus providing a potential target for lung cancer drugs.

ISO 690:

Zhang, L., Gao, L., Shao, M., Sun, G. 2019. A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth. In NEOPLASMA, vol. 66, no.6, pp. 954-962. 0028-2685.

APA:

Zhang, L., Gao, L., Shao, M., Sun, G. (2019). A MYC target long non-coding RNA GATA2-AS1 regulates non-small cell lung cancer growth. NEOPLASMA, 66(6), 954-962. 0028-2685.

Vydavateľ: AEPress, Ltd.