Post-weaning social isolation of rats induces reduction in the gene expression of vascular endothelial growth factor (VEGF) in the hippocampus

Rok, strany: 2019, 365 - 368

The role of vascular endothelial growth factor (VEGF) in chronic stress and neurodevelopmental disorders is of growing research interest. Here we show that post-weaning isolation rearing of rats decreased gene expression of VEGF in the hippocampus. Gene expression of VEGF upstream regulator fibroblast growth factor-2 (FGF-2) or its downstream mediator endothelial nitric oxide synthase (eNOS) was unchanged. Other signaling pathways appear to be involved in isolation-induced reduction in VEGF gene expression. Sex differences in VEGF and eNOS gene expression with significantly higher mRNA levels in females than males were revealed.

ISO 690:

Chmelova, M., Jezova, D., Riečanský, I., Hlavacova, N. 2019. Post-weaning social isolation of rats induces reduction in the gene expression of vascular endothelial growth factor (VEGF) in the hippocampus. In General Physiology and Biophysics, vol. 38, no.4, pp. 365-368. 0231-5882.

APA:

Chmelova, M., Jezova, D., Riečanský, I., Hlavacova, N. (2019). Post-weaning social isolation of rats induces reduction in the gene expression of vascular endothelial growth factor (VEGF) in the hippocampus. General Physiology and Biophysics, 38(4), 365-368. 0231-5882.