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FBLN3 inhibited the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway

In: NEOPLASMA, vol. 66, no. 3
Hy Mao - Sp Liu - Gm Kong - Y Xu - Yc Xu - Gz Sun - Z Wang - F Han - Jd Tong - P Bo
Detaily:
Rok, strany: 2019, 336 - 342
O článku:
Fibulin-3(FBLN3) levels are different in different types of cancers. We found that fibulin-3 was downregulated in colorectal (CRC) cells, particularly in the SW480 cell line. By comparison, transfecting SW480 cells with a lentivirus overexpressing fibulin-3 RNA could inhibit proliferation, induce G1/S arrest, and promote cell apoptosis. Fibulin-3 overexpression further suppressed the invasion and metastasis of CRC. These effects were regulated through the AKT/mTOR signaling pathway.
Ako citovať:
ISO 690:
Mao, H., Liu, S., Kong, G., Xu, Y., Xu, Y., Sun, G., Wang, Z., Han, F., Tong, J., Bo, P. 2019. FBLN3 inhibited the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway. In NEOPLASMA, vol. 66, no.3, pp. 336-342. 0028-2685.

APA:
Mao, H., Liu, S., Kong, G., Xu, Y., Xu, Y., Sun, G., Wang, Z., Han, F., Tong, J., Bo, P. (2019). FBLN3 inhibited the invasion and metastasis of colorectal cancer through the AKT/mTOR pathway. NEOPLASMA, 66(3), 336-342. 0028-2685.