miR-129-5p suppresses breast cancer proliferation by targeting CBX4

Rok, strany: 2018, 572 - 578

Dysregulation of microRNA (miRNA) is closely related to cancer development and progression. Our previous study has been identified that miR-129-5p suppresses the proliferation and metastasis in breast cancer cells. In this study, we aimed to explore the target gene of miR-129-5p. We found that CBX4, a member of CBXs, is a target of miR-129-5p. CBX4 is up-regulated in breast cancer tissues and overexpression of CBX4 promotes cell proliferation, whereas knockdown of CBX4 suppresses cell proliferation in breast cancer cells. Furthermore, CBX4 mediates miR-129-5p-induced inhibition of cell proliferation and is negatively related to the expression of miR-129-5p. Taken together, our data suggested that CBX4 is an oncogene in breast cancer cells, which may provide a novel therapeutic strategy for treatment of breast cancer.

ISO 690:

Meng, R., Fang, J., Yu, Y., Hou, L., Chi, J., Chen, A., Zhao, Y., Cao, X. 2018. miR-129-5p suppresses breast cancer proliferation by targeting CBX4. In NEOPLASMA, vol. 65, no.4, pp. 572-578. 0028-2685.

APA:

Meng, R., Fang, J., Yu, Y., Hou, L., Chi, J., Chen, A., Zhao, Y., Cao, X. (2018). miR-129-5p suppresses breast cancer proliferation by targeting CBX4. NEOPLASMA, 65(4), 572-578. 0028-2685.