In: NEOPLASMA, vol. 52, no. 1
C. Lakshmi - C. Deb - C. Ray - M. R. Ray
Detaily:
Rok, strany: 2005, 68 - 73
O článku:
Modulatory effects of dopamine (DA) on hematotoxicity and antitumor efficacy of cyclophosphamide (CY)
were studied in Swiss mice bearing transplantable Ehrlich ascites carcinoma (EAC).
DA was administered i.p. at a dose of 50 mg/kg/day for 5 consecutive days beginning day 3 after tumor transplantation.
CY (200 mg/kg i.p.) was injected 24 hour after completion of DA treatment. DA pretreatment reduced the suppressive
effects of CY on hemoglobin, RBC, total WBC, neutrophil, platelet, and bone marrow nucleated cell counts.
Likewise, DA partially prevented the CY-induced fall in pluripotent (CFU-S12) and lineage-specific stem cells for
granulocytes (CFU-C) in bone marrow. Moreover, mice receiving a combination of DA and CY illustrated greater
reduction in tumor volume, viable tumor cell count and mitotic index along with upregulation of tumor cell
apoptosis than CY-only group. As a result, the former group demonstrated prolonged hosts´ survival.
Thus, DA protected to a great extent the hematopoietic cells of tumor bearing hosts from the suppressive
action of CY and concomitantly augmented its antitumor efficacy resulting in improved hosts´ survival.
Ako citovať:
ISO 690:
Lakshmi, C., Deb, C., Ray, C., Ray, M. 2005. Reduction of hematotoxicity and augmentation of antitumor efficacy
of cyclophosphamide by dopamine. In NEOPLASMA, vol. 52, no.1, pp. 68-73. 0028-2685.
APA:
Lakshmi, C., Deb, C., Ray, C., Ray, M. (2005). Reduction of hematotoxicity and augmentation of antitumor efficacy
of cyclophosphamide by dopamine. NEOPLASMA, 52(1), 68-73. 0028-2685.