In: NEOPLASMA, vol. 51, no. 6
J. Lábaj - L. Wsolova - M. Lazarová - B. Košíková - D. Slameňová
Detaily:
Rok, strany: 2004, 450 - 455
O článku:
Living organisms possess a variety of self-protective mechanisms
which decrease the free radical attack on DNA and so reduce the
risk of cancer. Protection of DNA by endogenous antioxidant
systems may be significantly increased by numerous exogenously
administered antioxidants. Many of them represent important
dietary factors. Biopolymer lignin with its phenolic structure can
be included into this group of micronutrients. The aim of the
present work was to investigate: 1. the effect of biopolymer
lignin, given to Sprague-Dawley (SD) rats in diet, on the level of
oxidative DNA lesions induced by oxidative stress in freshly
isolated peripheral blood lymphocytes in vitro and 2. the
influence of lignin on kinetics of rejoining of DNA strand breaks
induced in lymphocytes under these conditions. As model oxidative
agents were used H2O2 and visible light in the presence of the
photosensitizer Methylene Blue. We found out that dietary intake
of lignin caused a significant decrease of H2O2-induced DNA strand
breaks and visible light-induced oxidative DNA lesions in freshly
isolated rat lymphocytes, but it did not influence the kinetics of
rejoining of DNA strand breaks.
Ako citovať:
ISO 690:
Lábaj, J., Wsolova, L., Lazarová, M., Košíková, B., Slameňová, D. 2004. Repair of oxidative DNA lesions in blood lymphocytes isolated from
Sprague-Dawley rats; the influence of dietary intake of lignin. In NEOPLASMA, vol. 51, no.6, pp. 450-455. 0028-2685.
APA:
Lábaj, J., Wsolova, L., Lazarová, M., Košíková, B., Slameňová, D. (2004). Repair of oxidative DNA lesions in blood lymphocytes isolated from
Sprague-Dawley rats; the influence of dietary intake of lignin. NEOPLASMA, 51(6), 450-455. 0028-2685.