In: NEOPLASMA, vol. 51, no. 6
S. Jantová - M. Theiszová - M. Mikulášová
Detaily:
Rok, strany: 2004, 436 - 441
O článku:
Nine substituted tetrazolo[1,5-c]quinazolines have been tested for
cytotoxic effects and structure activity relationship on the
murine cancer cell line B16 and four bacterial strains. The most
cytotoxic activity had non-substituted in the aromatic ring or
substituted by bromo- or chloro-group, and in the pyrimidine ring
of quinazoline skeleton by phenyl or morpholine group,
respectively. In the bacterium all tested quinazolines had a lower
antibacterial effect than ampicillin. 9-bromo-5-morpholino-tetrazolo[1,5-c]quinazoline (BMTQ) at the highest concentration
tested (30.0 μmol/l) had an acute cytostatic effect manifested by
the total inhibition of the cell proliferation. Other
concentrations caused a cytotoxicity proportional to the
concentation used. The IC50 values were found to be less than 4
μg/ml, a limit put forward by the National Cancer Institute (NCI)
for clasification of the compound as a potential anticancer drug.
BMTQ induced mutations in a dose-related manner, starting from 10
μg/plate in strains TA100 and TA102. Lesser but significant
increases in revertant colonies were also obtained in strain TA98.
The mutagenity was slighly enhanced by metabolic activation.
Ako citovať:
ISO 690:
Jantová, S., Theiszová, M., Mikulášová, M. 2004. Cytotoxic and genotoxic effects of some substituted tetrazolo[1,5-c]quinazolines. In NEOPLASMA, vol. 51, no.6, pp. 436-441. 0028-2685.
APA:
Jantová, S., Theiszová, M., Mikulášová, M. (2004). Cytotoxic and genotoxic effects of some substituted tetrazolo[1,5-c]quinazolines. NEOPLASMA, 51(6), 436-441. 0028-2685.