In: NEOPLASMA, vol. 51, no. 6
Z. Ovesná - A Vachálková - K. Horváthová
Detaily:
Rok, strany: 2004, 407 - 414
O článku:
Substantial attention has been given to primary cancer prevention
in daily life. Dietary factors are through to contribute to as
much as one-third of the factors influencing the development of
cancer. Ones of the components of a plant-based diet are β-
sitosterol and taraxasterol, compounds attracting our specific
attention. This review summarizes the biological activities of
presented phytosterols (anti-inflammatory, cholesterol-lowering,
anti-microbial, anti-bacterial, anti-fungal effects). Our interest
has been focussed especially on their anti-tumor and
chemopreventive activity. They have been shown experimentally to
inhibit colon and breast cancer development. They act at various
stages of tumor development, including inhibition of
tumorigenesis, inhibition of tumor promotion, and induction of
cell differentiation. They effectively inhibit invasion of tumor
cells and metastasis. With regard to toxicity, no obvious side
effects of phytosterols have been observed in studies to date,
with the exception of individuals with phytosterolemia. The exact
mechanism by which dietary phytosterols act is not fully
understood. However, some mechanisms have been offered. Therefore,
they have a bright future in clinical application. Further
investigation to explore their potential in tumor treatment may
prove to be worthwhile.
Ako citovať:
ISO 690:
Ovesná, Z., Vachálková, A., Horváthová, K. 2004. Taraxasterol and β-sitosterol: new naturally compounds with
chemoprotective/chemopreventive effects. In NEOPLASMA, vol. 51, no.6, pp. 407-414. 0028-2685.
APA:
Ovesná, Z., Vachálková, A., Horváthová, K. (2004). Taraxasterol and β-sitosterol: new naturally compounds with
chemoprotective/chemopreventive effects. NEOPLASMA, 51(6), 407-414. 0028-2685.