In: NEOPLASMA, vol. 51, no. 5
M. Hermanová - R. Nenutil - L. Křen - J. Feit - Z. Pavlovský - P. Dítě
Detaily:
Rok, strany: 2004, 400 - 404
O článku:
Patients with chronic pancreatitis have a markedly increased risk
of pancreatic cancer compared with general population. Mechanism
of the increased risk is not completely known. The current
progression model for pancreatic ductal adenocarcinoma proposes
the progression from normal ductal epithelium through a series of
lesions called pancreatic intraepithelial neoplasias (PanINs) to
invasive cancer. These lesions are frequently seen in chronic
pancreatitis tissue. Proliferative activity in PanINs of chronic
pancreatitis tissue has not been separately studied using the
current nomenclature. Our study included 36 chronic pancreatitis
resection specimens. A total number of 106 PanINs found within 32
resection specimens was histologically graded and then
immunolabeled using a monoclonal antibody against Ki-67 that is
expressed in dividing cells. The Ki-67 labeling indices in the
increasing grades of PanINs were counted with following results:
PanIN-1A, 0.77%; PanIN-1B, 3.26%; PanIN-2, 14.68%; and PanIN-3,
25.4%. The difference in Ki-67 labeling indices among these types
of lesions was statistically significant (p<0.001, t-test). These
results correlate with known genetic alterations found in chronic
pancreatitis, especially with p16 inactivation that was recently
described in PanINs arising in patients with chronic pancreatitis.
Moreover, our findings support the currently accepted pancreatic
progression model and Ki-67 immunohistochemistry might represent
an efficient tool for an identification of a high-risk lesion.
Ako citovať:
ISO 690:
Hermanová, M., Nenutil, R., Křen, L., Feit, J., Pavlovský, Z., Dítě, P. 2004. Proliferative activity in pancreatic intraepithelial neoplasias of
chronic pancreatitis resection specimens: detection of a high-risk
lesion. In NEOPLASMA, vol. 51, no.5, pp. 400-404. 0028-2685.
APA:
Hermanová, M., Nenutil, R., Křen, L., Feit, J., Pavlovský, Z., Dítě, P. (2004). Proliferative activity in pancreatic intraepithelial neoplasias of
chronic pancreatitis resection specimens: detection of a high-risk
lesion. NEOPLASMA, 51(5), 400-404. 0028-2685.