In: NEOPLASMA, vol. 51, no. 5
C. Kuropkat - A.a. Duenne - U. Herz - H. Renz - J.a. Werner
Detaily:
Rok, strany: 2004, 375 - 378
O článku:
Serum matrix metalloproteinases (MMPs) and the macrophage
colony-stimulating factor (M-CSF) are of potential interest as serum
tumor markers in various malignancies. There is still a lack of
reliable tumor markers in patients with squamous cell carcinoma of
the head and neck (SCCHN). Therefore, the tumor marker potential
of MMPs and M-CSF was investigated in these malignancies.
Serum of 59 patients suffering from SCCHN and of 59 healthy
volunteers was obtained. The concentration of MMP-3, MMP-8, MMP-9,
and M-CSF was determined by sandwich enzyme immunoassays. The MMP-
3, -8, -9, as well as the M-CSF serum concentrations were
significantly elevated in the patient group, compared to the
healthy controls (p<0.001, p<0.05, p<0.001, p=0.002). There was
significant correlation between the M-CSF and the MMP-3 serum
concentration (p<0.0001), and between the M-CSF and the MMP-8
serum concentration (p=0.005). A significant correlation with the
tumor stage was found only for MMP-8. MMP and M-CSF serum
concentrations are of potential interest as serum tumor markers in
SCCHN.
Ako citovať:
ISO 690:
Kuropkat, C., Duenne, A., Herz, U., Renz, H., Werner, J. 2004. Significant correlation of matrix metalloproteinase and macrophage
colony-stimulating factor serum concentrations in patients with
head and neck cancer. In NEOPLASMA, vol. 51, no.5, pp. 375-378. 0028-2685.
APA:
Kuropkat, C., Duenne, A., Herz, U., Renz, H., Werner, J. (2004). Significant correlation of matrix metalloproteinase and macrophage
colony-stimulating factor serum concentrations in patients with
head and neck cancer. NEOPLASMA, 51(5), 375-378. 0028-2685.