In: NEOPLASMA, vol. 51, no. 5
Z. Ovesná - A Vachálková - K. Horváthová - D. Tóthová
Detaily:
Rok, strany: 2004, 327 - 333
O článku:
Ursolic acid and oleanolic acid are pentacyclic triterpenoic acids
having a similar chemical structure and are the major components
of some oriental and traditional medicine herbs wildly distributed
all over the world. There is a growing interest in the elucidation
of the biological roles of both these triterpenoid compounds. This
review summarizes the biological activities of presented
triterpenoid acids (anti-inflammatory, hepatoprotective,
gastroprotective, anti-ulcer, anti-HIV, cardiovascular,
hypolipidemic, antiatherosclerotic and immunoregulatory effects).
Our interest has been focussed especially on their anti-tumor and
chemopreventive activity. Both compounds have been shown to act at
various stages of tumor development, including inhibition of
tumorigenesis, inhibition of tumor promotion, and induction of
tumor cell differentiation. They effectively inhibit angiogenesis,
invasion of tumor cells and metastasis. However, the mechanisms by
which they act are poorly understood. Ursolic acid and oleanolic
acid are relatively non-toxic and could be use as
chemopreventive/chemoprotective agens in clinical praxis.
Ako citovať:
ISO 690:
Ovesná, Z., Vachálková, A., Horváthová, K., Tóthová, D. 2004. Pentacyclic triterpenoic acids: new chemoprotective compounds. In NEOPLASMA, vol. 51, no.5, pp. 327-333. 0028-2685.
APA:
Ovesná, Z., Vachálková, A., Horváthová, K., Tóthová, D. (2004). Pentacyclic triterpenoic acids: new chemoprotective compounds. NEOPLASMA, 51(5), 327-333. 0028-2685.