Facebook Instagram Twitter RSS Feed PodBean Back to top on side

MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression

In: NEOPLASMA, vol. 65, no. 1
Tb Hu - Hs Chen - Mq Cao - Fd Guo - Xy Cheng - Zb Han - Mq Li
Detaily:
Rok, strany: 2018, 49 - 54
O článku:
Breast cancer is one of the most prevalent and fatal diseases around the world. The mechanism of tumorigenesis in breast cancer remains to be clarified. miR-421 plays an oncogenic roles in many cancers. But the clinical significance of miR-421 in patients with breast cancer is still to be investigated. Caspase-10 is one of the initiator in apoptosis. But the relationship between miR-421 and caspase-10 has not been investigated. In the present study, we found that miR-421 was expressed much higher in breast cancer tissues compared with those in adjacent non-tumor tissues. Furthermore, miR-421 promotes cell proliferation and colony formation in vitro. miR-421 inhibits cell apoptosis probably through restraining caspase-10 expression. Thus, miR-421 might be a potential diagnostic maker and therapeutic target for breast cancer.
Ako citovať:
ISO 690:
Hu, T., Chen, H., Cao, M., Guo, F., Cheng, X., Han, Z., Li, M. 2018. MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression. In NEOPLASMA, vol. 65, no.1, pp. 49-54. 0028-2685.

APA:
Hu, T., Chen, H., Cao, M., Guo, F., Cheng, X., Han, Z., Li, M. (2018). MicroRNA-421 inhibits caspase-10 expression and promotes breast cancer progression. NEOPLASMA, 65(1), 49-54. 0028-2685.