miR-215 promotes cell migration and invasion of gastric cancer cell lines by targeting FOXO1

Rok, strany: 2017, 579 - 587

Gastric cancer is one of the most common malignant tumor worldwide and has high morbidity and mortality. microRNAs are small, non-coding RNAs which play critical roles in the post-transcriptional regulation of gene expression. In this current study, we used qRT-PCR to detect miR-215 and FOXO1 expression level in 50 paired gastric cancer tissues and found that miR-215 was frequently overexpressed and FOXO1 was down-regulated in GC cancer tissues. Clinicopathological analysis showed that miR-215 expression level was correlated with the progression of tumor invasion and TNM stage. Additionally, transwell invasion assay showed that miR-215 promoted the migration and invasion of gastric cancer cells. We found that miR-215 decreased FOXO1 expression by directly binding to the 3’-untranslated region (UTR) of FOXO1. These results suggest that miR-215 promotes cell migration and invasion of gastric cancer by targeting FOXO1. Therefore, this study provides a promising therapeutic strategy for treating gastric cancer. Keywords: gastric cancer, miR-215, FOXO1, migration, invasion

ISO 690:

Zang, Y., Wang, T., Pan, J., Gao, F. 2017. miR-215 promotes cell migration and invasion of gastric cancer cell lines by targeting FOXO1. In NEOPLASMA, vol. 64, no.4, pp. 579-587. 0028-2685.

APA:

Zang, Y., Wang, T., Pan, J., Gao, F. (2017). miR-215 promotes cell migration and invasion of gastric cancer cell lines by targeting FOXO1. NEOPLASMA, 64(4), 579-587. 0028-2685.