miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1

Rok, strany: 2017, 526 - 534

Lung cancer is the most common type of cancer and the leading cause of death in worldwide. MicroRNAs are known to be key players in a variety of biological processes, including tumorigenesis. In present study, we investigated the effect of miR-361-5p on lung cancer progression. We found that miR-361-5p was down-regulated in lung cancer. Overexpression of miR-361-5p suppressed lung cancer proliferation and invasion. Mechanistically, FOXM1 was identified as a direct target of miR-361-5p. Furthermore, miR-361-5p inhibits EMT-like phenotype through down-regulation of FOXM1 expression in lung cancer cells. In conclusion, our results indicated that miR-361-5p acts as a tumor suppressor in lung cancer. Keywords: miR-361-5p, FOXM1, EMT, lung cancer

ISO 690:

Hou, X., Sun, X., Yu, Y., Zhao, H., Yang, Z., Wang, X., Cao, X. 2017. miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1. In NEOPLASMA, vol. 64, no.4, pp. 526-534. 0028-2685.

APA:

Hou, X., Sun, X., Yu, Y., Zhao, H., Yang, Z., Wang, X., Cao, X. (2017). miR-361-5p suppresses lung cancer cell lines progression by targeting FOXM1. NEOPLASMA, 64(4), 526-534. 0028-2685.