Predictors of survival in patients with brain metastases from gastric cancer

Rok, strany: 2017, 136 - 139

This study aims to identify predictors of survival and contribute to treatment personalization in patients with brain metastases from gastric cancer. Twelve patients received whole-brain radiotherapy (WBRT), four stereotactic radiosurgery and six neurosurgery plus WBRT. Treatment regimen, age, gender, Eastern Cooperative Oncology Group (ECOG) performance score, tumor site, number of brain metastases, extra-cranial metastases and interval between cancer diagnosis and brain metastases were evaluated for survival. On univariate analyses, more intensive treatment (p=0.003), ECOG-score 0-1 (p<0.001), cardiac location (p=0.025) and single brain metastasis (p=0.023) were associated with better survival. On multivariate analysis, ECOG-score maintained significance (p<0.001). Patients with all three positive factors on univariate analysis had a 12-month survival rate of 100%, patients with three negative factors a 3-month survival rate of 0%. Predictors of survival were identified that can guide physicians selecting personalized treatment approaches for patients with brain metastases from gastric cancer. Keywords: gastric cancer, cardiac cancer, brain metastases, radiotherapy, survival

ISO 690:

Rades, D., Bartscht, T., Schild, S. 2017. Predictors of survival in patients with brain metastases from gastric cancer. In NEOPLASMA, vol. 64, no.1, pp. 136-139. 0028-2685.

APA:

Rades, D., Bartscht, T., Schild, S. (2017). Predictors of survival in patients with brain metastases from gastric cancer. NEOPLASMA, 64(1), 136-139. 0028-2685.