miR-508-5p acts as an anti-oncogene by targeting MESDC1 in hepatocellular carcinoma

Rok, strany: 2017, 40 - 47

Hepatocellular carcinoma (HCC) is the third leading cause of cancer associated mortality. Accumulating evidence has shown that microRNAs (miRNAs) act as critical factors for tumor recurrence and metastasis. MiR-508-5p has been reported as a down-regulated miRNA in the primary gastric cancer tissues. However, the role of miR-508-5p on HCC has not been well elucidated. In this study, we observed that miR-508-5p was downregulated in HCC tissues when compared to the non-tumorous tissues. We then demonstrated that overexpression of miR-508-5p attenuated HepG2 cells proliferation and invasion and induced cell apoptosis in vitro. Furthermore, our further investigations revealed that mesoderm development candidate 1 (MESDC1) is a potential target of miR-508-5p, as well as miR-508-5p overexpression downregulated MESDC1 expression. Overexpression of MESDC1 promoted HepG2 cells migration, invasion and proliferation in vitro. In addition, miR-508-5p markedly suppressed the tumor growth in xenograft model, while MESDC1 promoted the tumor growth in xenograft model. This study provides new insight into molecular mechanisms that miR-508-5p acts as a tumor suppressor by targeting MESDC1 in HCC progression. Keywords: miR-508-5p, MESDC1, hepatocellular carcinoma

ISO 690:

Wu, S., Huang, Y., Bao, B., Wu, L., Dong, J., Liu, X., Li, Z., Wang, X., Wang, L., Chen, B., Chen, W. 2017. miR-508-5p acts as an anti-oncogene by targeting MESDC1 in hepatocellular carcinoma. In NEOPLASMA, vol. 64, no.1, pp. 40-47. 0028-2685.

APA:

Wu, S., Huang, Y., Bao, B., Wu, L., Dong, J., Liu, X., Li, Z., Wang, X., Wang, L., Chen, B., Chen, W. (2017). miR-508-5p acts as an anti-oncogene by targeting MESDC1 in hepatocellular carcinoma. NEOPLASMA, 64(1), 40-47. 0028-2685.