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β-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia

In: General Physiology and Biophysics, vol. 35, no. 2
Klara Hahnova - Dita Kasparova - Jitka Zurmanova - Jan Neckar - Frantisek Kolar - Jiri Novotny
Detaily:
Rok, strany: 2016, 165 - 173
O článku:
Chronic hypoxia may produce a cardioprotective phenotype characterized by increased resistance to ischemia-reperfusion injury. Nevertheless, the molecular basis of cardioprotective effects of hypoxia is still not quite clear. The present study investigated the consequences of a 3-week adaptation to cardioprotective (CNH, continuous normobaric hypoxia) and nonprotective (INH, intermittent normobaric hypoxia; 23 h/day hypoxia followed by 1 h/day reoxygenation) regimen of hypoxia on β-adrenergic signaling in the rat myocardium. Both regimens of hypoxia lowered body weight and led to marked right ventricular (RV) hypertrophy, which was accompanied by 25% loss of β1-adrenergic receptors (β1-ARs) in the RV. No significant changes were found in β-ARs in left ventricular (LV) preparations from animals adapted to hypoxia. Although adenylyl cyclase (AC) activity stimulated through the G proteins was decreased in the RV and increased in the LV after exposure to hypoxia, there were no significant changes in the expression of the dominant myocardial AC 5/6 isoforms and the stimulatory G proteins. These data suggest that chronic normobaric hypoxia may strongly affect myocardial β-adrenergic signaling but adaptation to cardioprotective and nonprotective regimens of hypoxia does not cause notably diverse changes.
Ako citovať:
ISO 690:
Hahnova, K., Kasparova, D., Zurmanova, J., Neckar, J., Kolar, F., Novotny, J. 2016. β-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia. In General Physiology and Biophysics, vol. 35, no.2, pp. 165-173. 0231-5882.

APA:
Hahnova, K., Kasparova, D., Zurmanova, J., Neckar, J., Kolar, F., Novotny, J. (2016). β-Adrenergic signaling in rat heart is similarly affected by continuous and intermittent normobaric hypoxia. General Physiology and Biophysics, 35(2), 165-173. 0231-5882.