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Endosialin: molecular and functional links to tumor angiogenesis

In: NEOPLASMA, vol. 63, no. 2
S. Kontsekova - K. Polcicova - M. Takacova - S. Pastoreková
Detaily:
Rok, strany: 2016, 183 - 192
O článku:
Endosialin, alternatively named tumor endothelial marker 1 (TEM1) or CD248, is a bulk transmembrane glycoprotein expressed both in developing and adult tissues undergoing active physiological or pathological angiogenesis. Endosialin is often overexpressed in tumors, particularly in stromal cells and in vessels-covering pericytes, and its transcription is induced by hypoxia via HIF-2 transcription factor. Based on the expression pattern, molecular characteristics and phenotypes of genetic models, endosialin has been proposed to function as a receptor implicated in sprouting angiogenesis, vasculogenesis and/or pruning of vessels. Here we provide an overview of the recent knowledge linking endosialin to diverse aspects of angiogenesis. Based on data-mining, our experimental data and available literature, we suggest that endosialin cross-talks with both pro- and anti-angiogenic signals and ECM components, and participates in dynamic vascular remodeling, which facilitates tumor growth. Tumor-selective targeting of endosialin may therefore contribute to improvement of existing anti-angiogenic therapies. Keywords: endosialin, angiogenesis, pericytes, extracellular matrix, cancer
Ako citovať:
ISO 690:
Kontsekova, S., Polcicova, K., Takacova, M., Pastoreková, S. 2016. Endosialin: molecular and functional links to tumor angiogenesis. In NEOPLASMA, vol. 63, no.2, pp. 183-192. 0028-2685.

APA:
Kontsekova, S., Polcicova, K., Takacova, M., Pastoreková, S. (2016). Endosialin: molecular and functional links to tumor angiogenesis. NEOPLASMA, 63(2), 183-192. 0028-2685.