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Association of BCSC-1 with human esophageal squamous cell carcinoma

In: NEOPLASMA, vol. 62, no. 5
C. Zhao - W. Yu - Z. Gao - W. Li - W. Gao - W. Yang - W. Feng - J. Ju
Detaily:
Rok, strany: 2015, 765 - 769
O článku:
Breast cancer suppressor candidate-1 (BCSC-1) is a newly identified candidate tumor suppressor gene. BCSC-1 shows decreased levels in a variety of cancer types. In this study, we investigated the association between BCSC-1 and human esophageal squamous cell carcinoma (ESCC). BCSC-1 expression was detected in ESCC and normal tissues adjacent to tumor tissues by Western blot analysis and real-time PCR  as well as immunohistochemistry of paraffin sections. The relationships between BCSC-1 expression and various clinicopathological characteristics were analyzed. Western blot analysis and real-time PCR showed that levels of BCSC-1 protein and mRNA expression in ESCC significantly decreased compared with those in adjacent normal tissues.  Immunohistochemistry exhibited marked reduction of BCSC-1 in 38 of 105 ESCC specimens. Moreover, downregulation of BCSC-1 was associated with the grade of tumor cellular differentiation (P<0.05). These findings indicate that BCSC-1 downregulation in ESCC is associated with carcinogenesis and may play important roles during the process of ESCC cancer development. Keywords: BCSC-1, ESCC, immunohistochemistry
Ako citovať:
ISO 690:
Zhao, C., Yu, W., Gao, Z., Li, W., Gao, W., Yang, W., Feng, W., Ju, J. 2015. Association of BCSC-1 with human esophageal squamous cell carcinoma. In NEOPLASMA, vol. 62, no.5, pp. 765-769. 0028-2685.

APA:
Zhao, C., Yu, W., Gao, Z., Li, W., Gao, W., Yang, W., Feng, W., Ju, J. (2015). Association of BCSC-1 with human esophageal squamous cell carcinoma. NEOPLASMA, 62(5), 765-769. 0028-2685.