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Acute toxicity of robotic ultrahypofractionated radiotherapy CyberKnifeTM in prostate cancer patients

In: NEOPLASMA, vol. 62, no. 4
G. Glowacki - W. Majewski - P. Wojcieszek - K. Grabinska - E. Chawinska - D. Bodusz - G. Wozniak - H. Urbanczyk - A. Kaletka - L. Miszczyk
Detaily:
Rok, strany: 2015, 674 - 682
O článku:
Our purpose was to evaluate the toxicity of CyberKnifeTM based fractionated stereotactic radiotherapy (FSRT) in prostate cancer patients. One-hunred-thirty-two men with low (62) and intermediate (70) prostate cancer were enrolled in our prospective study. Mean age was 69. Total dose of 36,25 Gy in 5 fractions was prescribed. Image guided FSRT was performed on CyberKnife. Minimum follow-up ranged from 3 to 28 months. EORTC/RTOG scale was used to evaluate toxicity. A total of 47%, 10% and 2% of patients presented grade 1, 2 and 3 acute genitourinary toxicity, respectively. In 25% and 3% of patients, respectively, grade 1 and 2 acute gastrointestinal toxicity was observed. No significant association between acute grade ≥ 2 toxicity and clinical factors: age, androgen deprivation therapy or infections were found. Neither CTV nor PTV volumes had significant impact on acute grade ≥ 2 toxicity. Late toxicity was assessed in 104 patients. In 16% and 1% of patients late GU toxicity in grade 1 and 2, respectively, was presented. Late GI toxicity grade 1, 2 and 3 occurred in 8%, 3% and 1% of patients, respectively. The acute toxicity rates of fractionated stereotactic radiotherapy are low. Early data suggest also low late toxicity rates. Keywords: CyberKnife, prostate cancer, toxicity, radiotherapy
Ako citovať:
ISO 690:
Glowacki, G., Majewski, W., Wojcieszek, P., Grabinska, K., Chawinska, E., Bodusz, D., Wozniak, G., Urbanczyk, H., Kaletka, A., Miszczyk, L. 2015. Acute toxicity of robotic ultrahypofractionated radiotherapy CyberKnifeTM in prostate cancer patients. In NEOPLASMA, vol. 62, no.4, pp. 674-682. 0028-2685.

APA:
Glowacki, G., Majewski, W., Wojcieszek, P., Grabinska, K., Chawinska, E., Bodusz, D., Wozniak, G., Urbanczyk, H., Kaletka, A., Miszczyk, L. (2015). Acute toxicity of robotic ultrahypofractionated radiotherapy CyberKnifeTM in prostate cancer patients. NEOPLASMA, 62(4), 674-682. 0028-2685.