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17-AAG enhances the cytotoxicity of flavopiridol in mantle cell lymphoma via autophagy suppression

In: NEOPLASMA, vol. 62, no. 3
Y. Xiao - J. Guan
Detaily:
Rok, strany: 2015, 391 - 397
O článku:
Flavopiridol, a cyclin-dependent kinase inhibitor (CDKI), shows promising anti-tumor activity in hematologic malignancies. However, Flavopiridol-induced protective autophagy may lead to drug resistance. Here we found that Hsp90 inhibitor 17-AAG can sensitize mantle cell lymphoma (MCL) cells to flavopiridol by suppressing flavopiridol-triggered protective autophagy. The suppressing effect of 17-AAG on autophgy was mediated by Beclin1 degradation and ERK inactivation. Furthermore, 17-AAG enhanced flavopiridol-induced apoptosis and growth suppression in MCL cells. Our study may provide some insights into CDKI -targeted chemotherapies. Keywords: flavopiridol, 17-AAG, MCL, autophagy
Ako citovať:
ISO 690:
Xiao, Y., Guan, J. 2015. 17-AAG enhances the cytotoxicity of flavopiridol in mantle cell lymphoma via autophagy suppression. In NEOPLASMA, vol. 62, no.3, pp. 391-397. 0028-2685.

APA:
Xiao, Y., Guan, J. (2015). 17-AAG enhances the cytotoxicity of flavopiridol in mantle cell lymphoma via autophagy suppression. NEOPLASMA, 62(3), 391-397. 0028-2685.