Cathepsin S as a cancer target

Rok, strany: 2015, 16 - 26

Cathepsin S is a lysosomal enzyme that belongs to the papain family of cysteine proteases. Multiple studies indicate that cathepsin S acts not only as a crucial role in antigen presentation but also as an important protagonist of cancers. Cathepsin S has been shown to participate in dissolution and remodelling of connective tissue and basement membranes, resulting in the process of tumor growth, invasion, metastasis and angiogenesis. Therefore, cathepsin S has been suggested as a potential therapeutic target in cancer therapy. In the present study, we review the rapidly advancing field of cathepsin S in cancer therapy, highlighting the specific roles of cathepsin S in cancer. Keywords: Cathepsin S, cancer, combined chemotherapy, inhibitors

ISO 690:

Zhang, L., Wang, H., Xu, J. 2015. Cathepsin S as a cancer target. In NEOPLASMA, vol. 62, no.1, pp. 16-26. 0028-2685.

APA:

Zhang, L., Wang, H., Xu, J. (2015). Cathepsin S as a cancer target. NEOPLASMA, 62(1), 16-26. 0028-2685.