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Heart ventricles specific stress-induced changes in β-adrenoceptors and muscarinic receptors

In: General Physiology and Biophysics, vol. 33, no. 3
Andrej Tillinger - Martina Novakova - Olga Krizanova - Richard Kvetnansky - Jaromir Myslivecek
Detaily:
Rok, strany: 2014, 357 - 364
O článku:
The left and right ventricles fulfill different role in heart function. Here we compare chamber specific changes in local catecholamine concentrations; gene expression and the receptor protein amount of all three β-adrenoceptors (β-AR) in rat right heart ventricles exposed to acute (1 session) and repeated (7 sessions) immobilization stress (IMMO) vs. previously observed changes in left ventricles. Density of muscarinic receptors as main cardio-inhibitive receptors was also measured. In the right ventricles, noradrenaline and adrenaline were increased. No β1-AR changes were observed, in spite of the increased sympathetic activity. On the other hand, we have found a decrease of β2-AR gene expression (reduction to 30%) after 7 IMMO and protein (to 59%) after 1 IMMO. β3-AR gene expression was increased after 7 IMMO. Muscarinic receptor density was not changed. When comparing correlation in left and right ventricles, there was strong correlation between adrenaline and β2-AR gene expression, protein and β3-AR gene expression in the left ventricles while only correlation between adrenaline and β2-AR mRNA and protein in the right ventricles was found. Our results show that maintenance of cardiac homeostasis under stress conditions are to a great extent achieved by a balance between different receptors and also by a balanced receptor changes in left vs. right ventricles. Taken together, decrease of cardio-stimulating β2-AR represents a new important mechanism by which β2-AR contributes to the heart physiology.
Ako citovať:
ISO 690:
Tillinger, A., Novakova, M., Krizanova, O., Kvetnansky, R., Myslivecek, J. 2014. Heart ventricles specific stress-induced changes in β-adrenoceptors and muscarinic receptors. In General Physiology and Biophysics, vol. 33, no.3, pp. 357-364. 0231-5882.

APA:
Tillinger, A., Novakova, M., Krizanova, O., Kvetnansky, R., Myslivecek, J. (2014). Heart ventricles specific stress-induced changes in β-adrenoceptors and muscarinic receptors. General Physiology and Biophysics, 33(3), 357-364. 0231-5882.