Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells

Year, pages: 2015, 201 - 207

Cytotoxic effects of essential oils extracted from Dunaliella salina on SH-SY5Y human neuroblastoma cells were investigated in this study. GC-MS analysis was used for determination of the composition of essential oils found in Dunaliella salina extract. All experimented concentrations of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells were significantly more cytotoxic than the tested concentrations of the extract on ECV304 human endothelial cells used as a control. Fifthy compounds were detected in GC-MS analysis of the extract, and five major compounds were predominantly found as follows: octadecanoic acid, methyl ester (27.43%); hexadecanoic acid, methyl ester (Cas) methyl palmitate (24.82%); 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z,Z)- (7.39%); octadecanoic acid (5.03%), pentadecanoic acid (3.60%). The cytotoxic activity of Dunaliella salina extract on SH-SY5Y human neuroblastoma cells might be due to high concentrations of octadecanoic acid and hexadecanoic acid. Furthermore, results indicate that the extract demonstrates some proliferative effect on ECV304 cells in a dose-dependent manner between 0.25 and 5 μg/ml. These results suggest that Dunaliella salina may have anticancer potential against human neuroblastoma cells.

Atasever-Arslan, B., Yilancioglu, K., Bekaroglu, M., Taskin, E., Altinoz, E., Cetiner, S. 2015. Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells. In General Physiology and Biophysics, vol. 34, no.2, pp. 201-207. 0231-5882.

Atasever-Arslan, B., Yilancioglu, K., Bekaroglu, M., Taskin, E., Altinoz, E., Cetiner, S. (2015). Cytotoxic effect of extract from Dunaliella salina against SH-SY5Y neuroblastoma cells. General Physiology and Biophysics, 34(2), 201-207. 0231-5882.