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The list of national projects SAS

Institute of Measurement Science
Analysis of multivariate time series and its application to research of functional connectivity in the brain
Analýza viacrozmerných časových radov a jej aplikácie na výskum funkčných prepojení v mozgu
Program: VEGA
Project leader: RNDr. Krakovská Anna CSc.
Annotation:The project is focused on the analysis of complex experimental time series. Applications will mainly concern the multi-channel electroencephalographic (EEG) signals measured from the human brain. We will be interested in functional connectivity between brain regions. The time series will not be examined in isolation, but as one of the manifestations of a complex system or subsystem. The analysis of simultaneously measured signals should help trace areas in the brain that are relatively independent or synchronized or causally affected by each other. Our focus will be on brain functional state changes during experiments focused on monitoring selected cognitive processes. We will also deal with the hypothesis of self-organized, scale-free, fractal processes in brain functioning. In terms of methodology, we would like to contribute to the development of multivariate causal methods, algorithms for multidimensional statistical analysis, and machine learning methods for the processing and analysis of EEG signals.
Duration: 1.1.2019 - 31.12.2021
Measurement and modeling of the cardiac electrical field for noninvasive identification and interpretation of structural changes of the ventricular myocardium leading to ventricular arrhythmias
Meranie a modelovanie elektrického poľa srdca na neinvazívnu identifikáciu a interpretáciu štrukturálnych zmien komorového myokardu vedúcich k ventrikulárnym arytmiám
Program: VEGA
Project leader: Ing. Švehlíková Jana PhD.
Annotation:The project is focused on the research of the measuring methods and processing of the electrical manifestation of the heart activity with the aim to diagnose myocardial structural changes or origins of the ventricular arrhythmias noninvasively. The main goal is a robust inverse solution for noninvasive localization and characterization of the origin of premature ventricular complexes and obtaining relevant medical information for radiofrequency ablation therapy. One part of the solution will be the methods for pathological heart activation modeling and computation of the potentials on the individual torso surface. The selection of an electrical generator model, heart activation process, and electrical parameters of the anisotropic torso allow optimization of the forward and inverse solution. To achieve the goals, advanced methods for ECG signals variability analysis as well as parallel computational methods will be proposed. A concept of ECG measuring system with a wireless data transfer will be developed.
Duration: 1.1.2019 - 31.12.2021
Personalized Optimisation of Cardiac Resynchronization Therapy in Heart Failure Based on Multiple Lead ECG Measurement
Personalizovaná optimalizácia resynchronizačnej liečby srdcového zlyhávania na základe mnohozvodového merania EKG
Program: SRDA
Project leader: Doc. Ing. Tyšler Milan CSc.
Annotation:Cardiac resynchronization therapy (CRT) is currently the most advanced therapeutic method for treatment of patients with failing heart. The essential criteria for patient indication for CRT are based on standard 12-lead ECG and echocardiographic measurements and include ECG pattern of left bundle branch block, prolongation of the QRS time interval, and left ventricular ejection fraction less than 35%. Despite most patients have a great benefit from the CRT, still 20-40% of patients do not profit from the therapy. On the other side, there is a considerable number of positive responders among patients not fulfilling the criteria. Therefore, there is a great effort to increase the success rate of the intervention and to find better criteria for its application. Current research shows that surface ECG maps recorded by a large number of electrodes, ECG imaging solving the inverse problem of electrocardiology and reconstructing the electrical activity of the heart, or combination of ECG imaging with computed tomography to identify structural damage of the myocardium have potential for more reliable detection of the electrical dyssynchrony and for suggesting optimal electrode placement and their timing. The main objective of the project is the research of methods for personalized optimization of the CRT therapy based on multi-lead surface ECG measurement and their verification on simulated data and data from real patients. The partial aims include: • finding such body surface potential maps parameters that could serve as suitable indicators of the electrical dyssynchrony of ventricles, • design of an inverse method for noninvasive localization of the latest activated areas in the ventricles and their use for placing the electrode in the left ventricle, • simulation of failing heart activation to understand the undergoing processes and their reflection in surface ECG signals, • development of a dedicated multi-lead ECG measuring system for personalized CRT optimization.
Duration: 1.7.2020 - 30.6.2023
Origin of amniotes: identification of key structures of the most-basal amniotes using computed microtomography
Pôvod amniótov: identifikácia kľúčových štruktúr najbazálnejších amniótov využitím počítačovej mikrotomografie
Program: VEGA
Project leader: RNDr. Hain Miroslav PhD.
Annotation:Our knowledge of the skeletal structures, on the basis of which it is possible to identify the most-basal amniotes, will be focused on the study: 1) of stem amniotes having an amphibian reproductive strategy, and 2) of the basal amniotes with the terrestrial reproductive strategy. Besides this, the investigation will be focused on the Parmo-Carboniferous group Diadectomorpha, the members of which play a key role as for the origin of amniotes. The first aim of the project is the knowledge of morphological transformations of the neurocranial structures during the evolutionary transition of tetrapods with amphibian reproductive strategy (Anamnia, the reproduction depending on external water) to tetrapods with reproduction not more depending on external water (Amniota, they leg the amniotic eggs on the land). The second aim is to evaluate all gained morphological data in the phylogenetic analysis to resolve the relationships of the investigated taxa at the transition stem amniotes – basal crown amniotes.
Duration: 1.1.2019 - 31.12.2021
Enhancing cognition and motor rehabilitation using mixed reality
Vylepšovanie kognície a motorickej rehabilitácie s využitím zmiešanej reality
Program: SRDA
Project leader: Ing. Mgr. Rosipal Roman PhD.
Annotation:Technological advancements based on mixed reality (MR) offer various challenges for research and medical treatment. The project focuses on two objectives related to healthy subjects and hemiparetic patients after stroke. First, we will test the hypothesis whether cognitive training using appropriately designed MR environment will enhance perceptual and cognitive performance in healthy subjects. This will be tested by computerized psychological experiments as well as by measuring event-related potentials or ERPs. Second, we will test the hypothesis whether experience with training in MR (in combination with motor-imagery based brain-computer interface developed by us) will enhance oscillatory sensory-motor rhythms. This will be tested by measuring subject’s EEG activity before and after each training session, clinical testing, as well as by the questionnaires aiming to learn about human factors including mental fatigue, motivation, irritation or sleepiness due to training. In both objectives, we will design and implement a set of testing procedures, carry out a battery of dedicated experiments, and critically evaluate the results with the goal to validate MR designs.
Duration: 1.7.2017 - 30.6.2021
Research of magnetic forms of iron in development of cardiovascular diseases and behavioural disorders
Výskum magnetických foriem železa v rozvoji kardiovaskulárnych chorôb a porúch správania
Program: SRDA
Project leader: Ing. Maňka Ján CSc.
Annotation:This project proposal is focused on the investigation of the role of iron in development of cardiovascular and behavioural disorders, prevalence of which is increasing during aging. The aim of this project is to investigate the impact of aging on the metabolism of biogenic iron and its magnetic properties in association with metabolic and functional alterations in the cardiovascular system and brain in rats with various genetic predispositions to hypertension. We will determine the molecular biological changes on the level of gene expression, their encoded proteins and the activities of the enzymes involved in the endogenous antioxidant protection, the regulation of nitric oxide production and cell death due to ferroptosis in course of aging. We will also investigate the impact of exogenously administered iron in the form of the biocompatible ultrasmall superparamagnetic iron oxide nanoparticles (USPIONs) on blood pressure regulation and function of the heart and blood vessels in conditions of normotension, chronically increased blood pressure and acute stress (i.e. acutely elevated blood pressure). Results achieved in this project will contribute to better understanding of the effects of the altered iron metabolism, magnetic forms of bodily iron, as well as iron in the form of USPIONs, on the cardiovascular and central nervous systems and to prevention of cardiovascular risk resulting from the use of USPIONs in targeted drug delivery or as the contrast materials for new imaging methods in medicine.
Duration: 1.7.2017 - 30.6.2021
Development and realisation of the standard of the static magnetic field based on a magnetic resonance
Vývoj a realizácia etalónu statického magnetického poľa na báze magnetickej rezonancie
Program: SRDA
Project leader: Ing. Andris Peter PhD.
Annotation:The main aim of the present project is the design of advanced NMR measurement methods using the most advanced range of systems (with a low magnetic field 0.05, 0.2, Tesla) for the development and implementation of standard static magnetic field on a magnetic resonance. This standard would be the basic calibration device for testing and calibration of the equipments that measure or generate magnetic field. The use of it would be in the Slovak Republic. Orientation research on: - theoretical and experimental research methods for the measurement and mapping of static magnetic fields, - standardizing the measurement metrology protocols, - mapping the intensity of the vibrations generated by the measuring system and modeling of their layouts for different measuring MRI sequences, - spectral analysis of disturbing signals, identification of dominant frequencies and evaluation of their effects on the accuracy and stability of the magnetic standard.
Duration: 1.7.2020 - 30.6.2023
Development of experimental platform and analytical tools for measurement of low frequency electromagnetic field effects on biological systems
Vývoj experimentálnej platformy a nástrojov analýzy na meranie účinkov nízkofrekvenčných elektromagnetických polí na biologické systémy
Program: VEGA
Project leader: Mgr. Teplan Michal PhD.
Annotation:The aim of the project is to develop measurement methods and analysis tools for identification of the effects of weak low frequency (LF) electromagnetic (EM) fields on selected biological systems. The main objective is the development of an automated experimental platform comprising multiple measurement stations, allowing monitoring and subsequent characterization of cell cultures. Main detection approaches include methods of impedance spectroscopy, turbidimetry, and optical microscopy. A complex hardware-software system will allow efficient scanning of frequencies and amplitudes of EM fields in order to identify parameters that lead to a specific response in the examined biosystems. Morphology and cell kinetics will be investigated by computer image analysis obtained from video-microscopy. The results will be analyzed for their possible applications in emergent problems of contemporary society.
Duration: 1.1.2019 - 31.12.2021
Development of innovative methods for primary metrology torque forces by force effects of the conventional standards
Vývoj inovatívnych metód pre primárnu metrológiu momentu sily aplikáciou silových účinkov konvenčnej etalonáže
Program: SRDA
Project leader: Doc. RNDr. Witkovský Viktor CSc.
Annotation:Torque is one of the main indicators for testing, respectively. testing a wide range of rotating machines and equipment. Measurements in the area over the last decades show a growing trend in terms of both quantity and quality requirements. This factor is also contributing to the growth of the automotive industry in Slovakia. Measuring momentum is inherently related to metrological continuity and the development of both industrial and secondary metrology. At present, however, the SR does not have a laboratory which, with its technical equipment and metrological quality, represents the highest level of primary metrology. The momentary force calibration laboratories in the SR are forced to look for sources of metrological continuity abroad. The aim of the project is therefore to lay the foundations of primary momentum metrology.
Duration: 1.7.2019 - 30.6.2022
Magnetic resonance imaging methods for medical diagnostics and material research.
Zobrazovacie metódy na báze magnetickej rezonancie pre medicínsku diagnostiku a materiálový výskum.
Program: VEGA
Project leader: Ing. Andris Peter PhD.
Annotation:Measurement, imaging and mapping of specific physical quantities of organic and synthetic materials and objects in the field of material and biomedical research development. Experimental and theoretical basic research on selected NMR-based imaging methods. The research will include methods for measuring and mapping the properties of specific physical quantities of organic and synthetic materials and objects. Research on the properties of weak magnetic nonliquids as part of contrast agents, thin magnetic layers. Study and selection of appropriate imaging methods with reference to biological and non-biological materials in magnetic fields 0.1, 0.2, 3.0, 4.7, 7.0 and 12.0 Tesla. Comparative imaging methods. Research on relaxation and dynamic mechanisms of action on liquid protons in magnetic resonance imaging. Methods of displaying cartilage and menisci - diagnosis of damage to connective tissues.
Duration: 1.1.2020 - 31.12.2022

The total number of projects: 10