The list of national projects SAS

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Institute: Institute of Experimental Physics

Atmospheric electricity and secondary cosmic radiation
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Program: Inter-academic agreement
Project leader: Mgr. Langer Ronald
Duration: 1.1.2018 - 31.12.2020

Cosmic rays as observed at two high mountain observatories: BEO Moussala and Lomnickf Sti
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Program: Inter-academic agreement
Project leader: Mgr. Langer Ronald
Duration: 1.1.2018 - 31.12.2020

Dynamical study of formation/destruction of protein amyloid aggregatess targeted by magnetic zeolite nanocomposites
Dynamické štúdium amyloidnej agregácie proteínov pomocou magnetických zeolitových nanočastíc
Program: Bilateral - other
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:Abnormal protein aggregation and accumulation of formed fibrils are characteristic features for a range of, if not all, neurodegenerative disorders such as Alzheimer’s, Huntington’s, Parkinson’s, as well as non-neuropathic amyloidosis. Nanoparticles (NPs), attributed to its particularities in sizes, chemical composition and surface properties, have already been found effective in influencing amyloid fibrils. Our preliminary results acquired on amyloid fibrils incubated with in-laboratory synthesized Fe3O4 nanoparticles (MNPs) indicated reductive potential of MNPs on formation of amyloid fibrils, and also suggested facilitation of inhibiting preformation and eradication of amyloid fibrils may be plausible when the fibrils are exposed to external radiation in presence of MNPs. Also, with our previously reported photoluminescence properties of natural zeolite (CZ) which is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms, organic molecules and nanoparticles into micro- and mesopores, we plan to apply the MNPs with CZ, developing multiphoton excitation microscopy (MPEM), and other appropriate instruments to establish the dynamical investigation of amyloid fibril formation and remodeling in real time. Prior to in vivo experiment, cytotoxicity in different type of cells and animal models such as zebrafish and mice will be evaluated.
Duration: 1.1.2018 - 31.12.2020

ALICE experiment at the CERN LHC: The study of strongly interacting matter under extreme conditions
Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach
Program: CERN
Project leader: RNDr. Králik Ivan CSc.
Annotation:The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties.
Duration: 1.1.2016 - 31.12.2020

ATLAS experiment on LHC in CERN: deep-inelastic events and new physics at TeV energies
Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách
Program: CERN
Project leader: Doc. RNDr. Bruncko Dušan CSc.
Duration: 1.1.2016 - 31.12.2020

JEM-EUSO, Extreme Universe Space Observatory Onboard Japan Experiment Module
JEM-EUSO, Kozmické Observatórium Extrémneho Vesmíru na palube Japonského Experimentálneho Modulu
Program: Multilateral - other
Project leader: RNDr. Bobík Pavol PhD
Annotation:Research of extreme energy cosmic rays with use of observations of secondary responses in the atmosphere of Earth from the International space station
Duration: 1.1.2010 - 31.12.2018

Design of nanostructured bio-hybrid materials through self-assembly process
Nanoštrukturované bio-hybridné materiály generované samousporiadajúcimi procesmi
Program: Bilateral - other
Project leader: RNDr. Tomašovičová Natália CSc.
Annotation:The aim of the present project proposal is to significantly contribute to the better understanding of the complex interaction between magnetic nanoparticles and host matrix based on the lyotropic liquid crystal. One of the key tasks of the project herein is to prepare bio-inorganic hybrids based on liquid crystals formed by lysozyme fibrils alongside doping of magnetic nanoparticles, to study the interaction between magnetic nanoparticles and lysozyme amyloid fibrils as well as their consequential structure. The project proposal primarily targets experimental research on a phenomenon observed in biological anisotropic colloidal suspensions, which have been extensively studied for its consequential relation with many human neurodegenerative disorders such as Alzheimers disease, Hungtingtons disease, and etc. Self-assembly of colloidal nanomaterials makes it possible to obtain structures with high level of ordering and permit construction of patterns to be used in optoelectronics, photonics and biosensing. However, the exact principle of mechanisms and the nature of the phenomenon are still unknown, and represent unexplored areas of research. Various experimental techniques already available at the collaborating institutions as detailed below will be employed to attain the main objective of the project as well as the related objectives itemized in the proposal.
Duration: 1.1.2018 - 31.12.2019

Non-globular proteins - from sequence to structure, function and application in molecular physiopathology
Neglobulárne proteíny - od sekvencie ku štruktúre, funkcii a aplikácii v molekulárnej fyziopatológii
Program: COST
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Non-globular proteins (NGPs) encompass different molecular phenomena that defy the traditional sequence-structure-function paradigm. NGPs include intrinsically disordered regions, tandem repeats, aggregating domains, low-complexity sequences and transmembrane domains. Although growing evidence suggests that NGPs are central to many human diseases, functional annotation is very limited. It was recently estimated that close to 40 of all residues in the human proteome lack functional annotation and many of these are NGPs. While a better understanding of NGPs is crucial to fully comprehend human molecular physiopathology, progress has been hampered so far by the lack of a systematic approach to their study.This Action Proposal aims to create a pan-European scientific network of groups that work on NGPs to strengthen, focus and coordinate research in this field. It proposes to develop a novel classification of NGPs by consensus among interested experts that will be showcased on a newly developed web site, along with meetings, training schools and scientific missions on NGP-related topics.
Duration: 27.7.2015 - 25.3.2019

New MAGnetic Biomaterials for Brain Repair and Imaging after Stroke
Nové magnetické biomateriály pre obnovu mozgu a zobrazovanie po mozgovej príhode
Program: ERANET
Project leader: Doc. RNDr. Kopčanský Peter CSc.
Annotation:By engineering novel magnetic nano-biomaterials we will achieve tissue repair in the context of an ischemic event. We will take advantage of nanotechnology to deliver therapeutic growth factors, secreted by progenitor cells, into the injured brain. According to the World Health Organization, 15 million persons suffer a stroke worldwide eachyear. However, the only available treatment is the acute thrombolytic therapy (pharmacological or mechanical) which is being administered to less than 10% of stroke patients due to strict selectioncriteria. In contrast, neuro-repair treatments could offer the opportunity to include most strokepatients by extending the therapeutic time window. MAGBBRIS will demonstrate that growth factors, secreted by endothelial progenitor cells, with proved potential to induce tissue repair, can be encapsulated in magnetic biomaterials and be successfully and safely transplanted into mouse brains to induce tissue repair. In the ischemic brain, the secretome will be retained by an external magnetic field in the vasculature, improving vascular remodelling and neurogenic tissue regeneration after stroke.
Duration: 1.3.2018 - 31.12.2020

Overcoming Barriers to Nanofluids Market Uptake ( NANOUPTAKE)
Prekonanie bariiér pre komerčné využitie nanokvapalín (NANOUPTAKE)
Program: COST
Project leader: RNDr. Timko Milan CSc.
Annotation:Nanofluids are defined as fluids that contain nanometre-sized particles with enhanced heat transfer properties. Nanofluids improve the efficiency of heat exchange and thermal energy storage. In addition, nanofluids fall within one of the Key Enabling Technologies (KET) supported by the European Commission. Although some nanofluid commercial applications currently exist, most of the current nanofluids are at Technological Readiness Levels (TRL) 1 to 3. Most of the nanofluids research in COST countries has been conducted by Research, Development and Innovation (R+D+i) centres through national funding. Additional coordinated research and development efforts are required to develop nanofluids up to higher TRL levels and to overcome commercial application barriers. If these barriers are overcome, nanofluids will be an important player in the Value Added Materials (VAM) for the energy sector.The objective of the NANOUPTAKE COST Action is to create a Europe-wide network of leading R+D+i institutions, and of key industries, to develop and foster the use of nanofluids as advanced heat transfer/thermal storage materials to increase the efficiency of heat exchange and storage systems.
Duration: 19.4.2016 - 18.4.2020

Research on preparation and magnetic properties of Co/CoO core-shell nanoparticles
Príprava a magnetické vlastnosti Co/CoO core-shell nanočastíc
Program: Inter-academic agreement
Project leader: RNDr. Škorvánek Ivan CSc.
Duration: 1.1.2018 - 31.12.2019

Study of the protein amyloid aggregation in vitro and in cerebrospinal fluid
Štúdium amyloidnej agregácie proteínov in vitro a v mozgomiešnom moku
Program: Inter-institute agreement
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:Study of the amyloid aggregation of the protein in vitro and in the samples of the cerebrospinal fluid of the peoples with amyloid-related disease which obtain protein aggregation in vivo.Test of the assay for cerebrospinal fluid of the dementic and non-dementic peoples.
Duration: 13.7.2015 - 31.12.2020

Theoretical and experimental studies of orientational, magneto-optical and dielectric properties of composite liquid crystals filled with magnetic particles.
Teoretické a experimentálne štúdium orientačných, magneto-optických a dielektrických vlastností kompozitov kvapalných kryštálov dopovaných magneticckými časticami.
Program: Inter-academic agreement
Project leader: RNDr. Tomašovičová Natália CSc.
Annotation:At the last decades, one of the important areas of modern soft matter physics is theoretical and experimental study of liquid crystals (LC) which are very attractive for use in various commercial exploitations. The great interest of researchers to this area of science is explained, first of all, by fast development of electronic technique and communication equipments which require reliable, convenient and compact devices for processing and displaying information – indicators, displays, screens, etc. The successful use of LC materials in such devices considerably expanded a circle of technical applications of liquid crystals: now they are applied also in modern industrial machineries, in different transport vehicles and systems, medicine, household appliances, etc. Additionally, the search for new materials with exotic properties and for new technologies continues, in order to comply with the needs of these, and other novel applications.
Duration: 1.1.2017 - 31.12.2019

Effect of small molecules and nanoparticles on amyloid aggregation of poly/peptides
Účinok malých molekúl a nanočastíc na amyloidnú agregáciu poly/peptidov
Program: Bilateral - other
Project leader: doc. RNDr. Gažová Zuzana CSc.
Annotation:This project is aimed at examining the self-assembly of proteins into amyloid aggregates, one of the hallmarks of AD and other amyloidosis. Accordingly, there is a considerable world-wide interest to identify molecular entities that can influence the amyloid aggregation in order to facilitate the drug development for amyloid diseases. The main goals of the project are to estimate the conditions required for promoting protein misfolding, to determine the cytotoxicity of amyloid aggregates, and to identify the compounds (e.g. small molecules and nanoparticles) that are able to inhibit protein aggregation using in vitro and in silico methods. The bilateral collaboration will allow to combine expertise and experience of both partners in the field of protein aggregation and acquire complex data with aid of complementary approaches, leading to a better understanding of amyloid aggregation mechanisms. The use of equipment provided by both institutions will offer a solid background for team members in order to publish their results at conferences and in journals. Moreover, this collaborative research partnership will present an excellent opportunity for both teams’ young members to learn new techniques in the well-equipped laboratories at NTU and SAS and work as an international scientific research group.
Duration: 11.1.2016 - 31.12.2018

The total number of projects: 14