The list of national projects SAS

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Institute: Institute of Parasitology

Combatting anthelmintic resistance in ruminants
Boj proti rezistencii na antihelmintiká u prežúvavcov
Program: COST
Project leader: doc. MVDr. Várady Marián DrSc.
Duration: 1.9.2017 - 1.9.2021

In vivo activity of silymarin flavonolignans on model infection induced with cestode Mesocestoides vogae in mice.
In vivo aktivita silymarínových flavonolignanov na modelovú infekciu vyvolanú pásomnicou Mesocestoides vogae u myší.
Program: Inter-academic agreement
Project leader: RNDr. Hrčková Gabriela DrSc.
Annotation:Medically important species of cestodes Echinococcus multilocularis, E. granulosus, Taenia solium cause serious diseases in various hosts, while humans can be infected accidentally. It is estimated that millions of people suffer from these disease mostly in resource-poor communities worldwide with limited therapeutic possibilities. Infection with cestode Mesocestoides vogae shares many pathological and molecular similarities with these diseases and was recommended by WHO (1996) as a suitable model in pharmacological, molecular and immunological studies. Silymarin represents mixture of flavonolignans, namely silybin, isosilibyn A, silydianin and silychristin. The pleiotropic mode of action of silymarin (antioxidant, antifibrotic, immunomodulatory, anti-cancer) has been reported but cestocidal potential of silymarin flavonolignans has not been studied in vivo. Recently we have demonstrated profound larvicidal activity due to interference with metabolic and enzymatic pathways in M. vogae larvae. The objective of present project is to reveal complex effects of individual flavonolignans during M. vogae infection in BALB/c mice.
Duration: 1.1.2018 - 31.12.2020

Aedes Invasive Mosquitoes
Invazívne komáre rodu Aedes
Program: COST
Project leader: MVDr. Miterpáková Martina PhD.
Duration: 1.3.2019 - 1.9.2022

Classical and molecular karyology of Diphyllobothrium parasites: detection of phylogenetically informative markers.
Klasická a molekulárna karyológia parazitov rodu Diphyllobothrium: detekcia fylogeneticky významných charakteristík.
Program: Inter-academic agreement
Project leader: RNDr. Orosová Martina PhD.
Annotation:The current project is focused on cytogenetic research of medically important zoonotic parasites of the genus Diphyllobothrium. Karyotypes will be described in selected representatives and macro- and microstructure of chromosomes will be analyzed using both classical and molecular approaches. Methods of molecular karyology will be applied for the first time in this cestodes group. Fluorescence in situ hybridization enables detection of number and location of ribosomal genes as well as genes for histones H3 and H4. The key outputs arising from this project will be new description and re-description of karyotypes, and detailed molecular cytogenetic analysis of chromosomes. The newly obtained complex cytogenetic data will be, in combination with new molecular and morphological data, used for the revision of phylogenetic relationships between tapeworms of the genus Diphyllobothrium as well as at the level of the family Diphyllobothriidae.
Duration: 1.1.2018 - 31.12.2020

Parasites in domestic and wild carnivores from Slovakia and Bulgaria in the era of global changes
Parazity domácich a voľne žijúcich mäsožravcov na Slovensku a v Bulharsku v období globálnych zmien
Program: Inter-academic agreement
Project leader: MVDr. Hurníková Zuzana PhD.
Annotation:Free living carnivores are involved in maintenance and spread of several viral, bacterial and parasitic zoonotic diseases; potentially transmissible to domestic, farm and game animals, and also to humans. The project is focused at comparison of the parasite fauna composition of domestic and free living carnivores in both Bulgaria and Slovakia including parasitic agents transmissible to man. The occurrence of parasites in ecologically different areas will be collated and the host-parasite-landscape interactions studied. Molecular characteristic of parasite strains as well as the homology of isolates obtained in selected areas will provide the basis for evaluation of possible spread of parasites from south (Bulgaria) northward (Slovakia. The risk factors that advance the parasite circulation and risk areas of increased appearance of reservoirs, vectors and potential hosts with respect to spread of parasitic infections will be identified.
Duration: 1.1.2018 - 31.12.2020

Transmission patterns and genetic polymorphisms of zoonotic Echinococcus tapeworms in central Europe
Transmisné cykly a genetické polymorfizmy zoonóznych pásomníc rodu Echinococcus v strednej Európe
Program: Bilateral - other
Project leader: RNDr. Šnábel Viliam CSc.
Annotation:Alveolar echinococcosis is of increasing public health concern in central Europe, as human cases appear to be increasingly frequent. The impact of landscape, host animals and genetic variability of the parasite on infection risk and pathogenicity is not yet fully understood. A specific issue will be a survey of clade composition of Echinococcus multilocularis in selected European and Russian/Siberian areas that might contribute to better understanding of its evolutionary history and how the parasite spread worldwide. Cystic echinococcosis continues to be a frequent livestock disease in southern and eastern Europe. From gained data, more effective public health policies to reduce E. granulosus s.l. transmission will be implemented, also with regard to prevent precursors to regional and global expansions associated with trade.
Duration: 1.1.2019 - 31.12.2020

The place of carnivores in transmission diseases of zoonotic foci
Úloha mäsožravcov pri prenose chorôb v zoonotickom ložisku
Program: Inter-academic agreement
Project leader: RNDr. Víchová Bronislava PhD.
Duration: 1.1.2019 - 31.12.2021

Eggs ultrastructure of the basal tapeworm groups (Caryophyllidea, Diphyllobothriidea)
Ultraštruktúra vajíčok bazálnych skupín pásomníc (Caryophyllidea, Diphyllobothriidea)
Program: Inter-academic agreement
Project leader: RNDr. Bruňanská Magdaléna DrSc.
Duration: 1.1.2018 - 31.12.2020

Wild carnivores as a reservoir of zoonotic diseases in the north-eastern Poland
Voľne žijúce mäsožravce ako rezervoár zoonónych ochorení na území severovýchodného Poľska
Program: Inter-academic agreement
Project leader: MVDr. Dvorožňáková Emília PhD.
Annotation:Wild carnivores are an important reservoir for zoonotic diseases and play a significant role in their transmission to humans. The aim of the project is to study occurrence of such zoonotic diseases as: trichinellosis, echinococcosis, toxocarosis, babesiosis, anaplasmosis, mycoplasmosis, and borreliosis in wild carnivores inhabiting north-eastern Poland. Partially collected material and routinely used methods will provide reliable results. It will be the first complex study showing the species - specific pattern of carnivore hosts for zoonotic diseases in north-eastern Poland.
Duration: 1.1.2019 - 31.12.2021

The total number of projects: 9