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Institute: Institute of Parasitology

Combatting anthelmintic resistance in ruminants
Boj proti rezistencii na antihelmintiká u prežúvavcov
Program: COST
Project leader: doc. MVDr. Várady Marián DrSc.
Duration: 1.9.2017 - 1.9.2021

In vivo activity of silymarin flavonolignans on model infection induced with cestode Mesocestoides vogae in mice.
In vivo aktivita silymarínových flavonolignanov na modelovú infekciu vyvolanú pásomnicou Mesocestoides vogae u myší.
Program: Inter-academic agreement
Project leader: RNDr. Hrčková Gabriela DrSc.
Annotation:Medically important species of cestodes Echinococcus multilocularis, E. granulosus, Taenia solium cause serious diseases in various hosts, while humans can be infected accidentally. It is estimated that millions of people suffer from these disease mostly in resource-poor communities worldwide with limited therapeutic possibilities. Infection with cestode Mesocestoides vogae shares many pathological and molecular similarities with these diseases and was recommended by WHO (1996) as a suitable model in pharmacological, molecular and immunological studies. Silymarin represents mixture of flavonolignans, namely silybin, isosilibyn A, silydianin and silychristin. The pleiotropic mode of action of silymarin (antioxidant, antifibrotic, immunomodulatory, anti-cancer) has been reported but cestocidal potential of silymarin flavonolignans has not been studied in vivo. Recently we have demonstrated profound larvicidal activity due to interference with metabolic and enzymatic pathways in M. vogae larvae. The objective of present project is to reveal complex effects of individual flavonolignans during M. vogae infection in BALB/c mice.
Duration: 1.1.2018 - 31.12.2020

Classical and molecular karyology of Diphyllobothrium parasites: detection of phylogenetically informative markers.
Klasická a molekulárna karyológia parazitov rodu Diphyllobothrium: detekcia fylogeneticky významných charakteristík.
Program: Inter-academic agreement
Project leader: RNDr. Orosová Martina PhD.
Annotation:The current project is focused on cytogenetic research of medically important zoonotic parasites of the genus Diphyllobothrium. Karyotypes will be described in selected representatives and macro- and microstructure of chromosomes will be analyzed using both classical and molecular approaches. Methods of molecular karyology will be applied for the first time in this cestodes group. Fluorescence in situ hybridization enables detection of number and location of ribosomal genes as well as genes for histones H3 and H4. The key outputs arising from this project will be new description and re-description of karyotypes, and detailed molecular cytogenetic analysis of chromosomes. The newly obtained complex cytogenetic data will be, in combination with new molecular and morphological data, used for the revision of phylogenetic relationships between tapeworms of the genus Diphyllobothrium as well as at the level of the family Diphyllobothriidae.
Duration: 1.1.2018 - 31.12.2020

Emerging and Re-emerging Zoonotic Parasitosis Caused by Fish-Borne Parasites: Health Risks Associated with Consumption of Fish
Novo sa objavujúce rybami prenášané zoonózy: zdravotné riziká spojené s konzumáciou rýb
Program: JRP
Project leader: RNDr. Oros Mikuláš PhD.
Annotation:Consume raw and improperly cooked fishes may transmit fish-borne zoonotic diseases, which are currently (re-)emerging also due to population movement and climate changes. The aims of proposed collaborative project are focused on to the assessment of present occurrence, host associations, and current distribution and transmission routes of potential causative agents of fish-borne diseases in Taiwan as an important endemic area. Trematodes (Clonorchis, Metagonimus, Haplorchis) responsible for human liver and intestinal infection, respectively, broad fish tapeworm (Diphyllobothrium) causing diphyllobothriosis and the anisakid nematodes (e.g. Anisakis simplex) causing human anisakiosis, will serve as model parasite groups. The novelty of the project lies in its interdisciplinary character, i.e., application of different methodological approaches, e.g., morphology, ultrastructure, phylogeography, phylogenetics and molecular karyology. The project will be based on international cooperation with a key role of Slovak parasitologists experienced in multidisciplinary studies on the helminth parasites including causative agents of zoonotic diseases and fish surveys to detect their infective stages.
Duration: 1.3.2017 - 31.12.2019

Parasites in domestic and wild carnivores from Slovakia and Bulgaria in the era of global changes
Parazity domácich a voľne žijúcich mäsožravcov na Slovensku a v Bulharsku v období globálnych zmien
Program: Inter-academic agreement
Project leader: MVDr. Hurníková Zuzana PhD.
Annotation:Free living carnivores are involved in maintenance and spread of several viral, bacterial and parasitic zoonotic diseases; potentially transmissible to domestic, farm and game animals, and also to humans. The project is focused at comparison of the parasite fauna composition of domestic and free living carnivores in both Bulgaria and Slovakia including parasitic agents transmissible to man. The occurrence of parasites in ecologically different areas will be collated and the host-parasite-landscape interactions studied. Molecular characteristic of parasite strains as well as the homology of isolates obtained in selected areas will provide the basis for evaluation of possible spread of parasites from south (Bulgaria) northward (Slovakia. The risk factors that advance the parasite circulation and risk areas of increased appearance of reservoirs, vectors and potential hosts with respect to spread of parasitic infections will be identified.
Duration: 1.1.2018 - 31.12.2020

Joint investigation of fish parasite diversity in the Yangtze River basin: uncovering the hidden species diversity and exotic invasions
Spoločný výskum parazitov rýb v povodí rieky Yangtze: odhalenie skrytej druhovej diverzity a exotické invázie
Program: Bilateral - other
Project leader: RNDr. Oros Mikuláš PhD.
Annotation:China is zoogeographically remarkable area where the Palaearctic and Oriental faunas come into contact. There are several faunistic reports on tapeworms from various fish hosts, but complex taxonomical and genetic research on these parasites is relatively limited. Validity of numerous Chinese taxa is still questionable. The proposed collaborative project aims at obtaining new data on the fish parasites from the Yangtze River basin, with focus on poorly- studied regions and taxonomically problematic taxa. Taxonomical revisions, genetic structure and detailed karyotype research, including descriptions of new taxa and unknown karyotypes, will be performed. The novelty of the project is application of a wide array of approaches (alpha-taxonomy and morphology, modern tools of genetics and karyology) which will enable us to obtain an original and extensive data set applicable to further faunistic, taxonomic and phylogenetic studies. The project also has important outcomes for theoretical parasitology and veterinary practice, because detailed information about potential pathogens of cultured fish and invasive species will also be provided. The tapeworms of the order Caryophyllidea (Cestoda), representatives of phylogenetically old, so-called basal tapeworms, are typical component of the parasite fauna of China, that have been well studied in our laboratory before have been selected as principal model parasite groups.
Duration: 1.1.2018 - 31.12.2019

Eggs ultrastructure of the basal tapeworm groups (Caryophyllidea, Diphyllobothriidea)
Ultraštruktúra vajíčok bazálnych skupín pásomníc (Caryophyllidea, Diphyllobothriidea)
Program: Inter-academic agreement
Project leader: RNDr. Bruňanská Magdaléna DrSc.
Duration: 1.1.2018 - 31.12.2020

The total number of projects: 7