Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets

In: General Physiology and Biophysics, vol. 25, no. 2

B Olas - P Nowak - M Ponczek - B Wachowicz

Detaily:

Rok, strany: 2006, 215 - 222

O článku:

Resveratrol (3,4’,5-trihydroxystilbene) has a very broad range of biological properties, including antiplatelet and antioxidative activity. We investigated in vitro the effect of resveratrol on carbonylation of proteins (indicators of oxidative stress) in blood platelets treated with peroxynitrite (ONOO^-), a strong biological oxidant and inflammatory mediator. We observed that carbonylation of proteins induced by ONOO^- (0.1 mmol/l), in the presence of resveratrol (0.25–0.1 mmol/l) is reduced. Resveratrol may scavenge ONOO^-, and may be useful in the prevention of ONOO^--related diseases, such as inflammatory and cardiovascular diseases.

Ako citovať:

ISO 690:

Olas, B., Nowak, P., Ponczek, M., Wachowicz, B. 2006. Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets. In General Physiology and Biophysics, vol. 25, no.2, pp. 215-222. 0231-5882.

APA:

Olas, B., Nowak, P., Ponczek, M., Wachowicz, B. (2006). Resveratrol, a natural phenolic compound may reduce carbonylation proteins induced by peroxynitrite in blood platelets. General Physiology and Biophysics, 25(2), 215-222. 0231-5882.